79267

Trimethylphenylammonium hydroxide solution

~25% in H₂O (1.68 M)

• Synonyme(s) : Phenyltrimethylammonium hydroxide, TMAH
• Formule linéaire : (CH₃)₃N(OH)C₆H₅
• CAS Number: 1899-02-1
• Poids moléculaire : 153.22
• Beilstein: 3917033
• Numéro MDL: MFCD00041899
• Code UNSPSC : 12352005
• ID de substance PubChem : 57652783
• Nomenclature NACRES : NA.22

Propriétés

• Forme: liquid
• Niveau de qualité: 100
• Concentration: ~25% in H₂O (1.68 M)
• Indice de réfraction: n20/D 1.395
• Groupe fonctionnel: amine
• Chaîne SMILES: [OH-].C[N+](C)(C)c1ccccc1
• InChI: 1S/C9H14N.H2O/c1-10(2,3)9-7-5-4-6-8-9;/h4-8H,1-3H3;1H2/q+1;/p-1
• Clé InChI: HADKRTWCOYPCPH-UHFFFAOYSA-M

Description

Description générale

Trimethylphenylammonium hydroxide solution (TMPAH) is a quaternary ammonium compound that is commonly used as a strong base in organic synthesis. It is also used as a deprotecting agent for the removal of t-butoxycarbonyl (Boc) groups from amino acids or peptides and benzyl protecting groups from alcohols or amines.

Application

Trimethylphenylammonium hydroxide solution can be used to initiate the polymerization of the monomer 1,8-dihydroxymethyl-1,3,5,7-octatetrayne (DHOT) for the preparation of polymer nanospheres. It is also used as a base in the synthesis of alkyl 3-nitroacrylates via aldol reaction with nitroacetaldehyde or nitroacetone.

Informations sur la sécurité

• Pictogrammes: GHS05
• Mention d'avertissement: Danger
• Mentions de danger: H314
• Conseils de prudence: P280 - P301 + P330 + P331 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P363
• Classification des risques: Eye Dam. 1 - Skin Corr. 1B
• Code de la classe de stockage: 8A - Combustible corrosive hazardous materials
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter