799718

AlPhos

• Synonyme(s) : Di-1-adamantyl(4″-butyl-2″,3″,5″,6″-tetrafluoro-2′,4′,6′-triisopropyl-2-methoxy-meta-terphenyl)phosphine
• Formule empirique (notation de Hill) : C₅₂H₆₇F₄OP
• CAS Number: 1805783-60-1
• Poids moléculaire : 815.06
• Numéro MDL: MFCD00626457
• Code UNSPSC : 12161600
• ID de substance PubChem : 329768101
• Nomenclature NACRES : NA.22

Propriétés

• Essai: ≥95%
• Niveau de qualité: 100
• Forme: powder
• Capacité de réaction: reaction type: Buchwald-Hartwig Cross Coupling Reaction; reaction type: Heck Reaction; reaction type: Hiyama Coupling; reaction type: Negishi Coupling; reaction type: Sonogashira Coupling; reaction type: Stille Coupling; reaction type: Suzuki-Miyaura Coupling
• Pertinence de la réaction: reagent type: ligand; reaction type: Cross Couplings
• Pf: 218-223 °C
• Groupe fonctionnel: phosphine
• Température de stockage: −20°C
• InChI: 1S/C52H67F4OP/c1-9-10-12-38-46(53)48(55)45(49(56)47(38)54)44-40(29(4)5)21-39(28(2)3)43(42(44)30(6)7)37-13-11-14-41(57-8)50(37)58(51-22-31-15-32(23-51)17-33(16-31)24-51)52-25-34-18-35(26-52)20-36(19-34)27-52/h11,13-14,21,28-36H,9-10,12,15-20,22-27H2,1-8H3/t31-,32+,33?,34-,35+,36?,51+,52?,58?
• Clé InChI: ALWIRDZSIXWCBO-VABCSHEKSA-N

Description

Application

AlPhos is a biaryl monophosphine ligand that can be used:

• In the Pd-catalyzed Buchwald-Hartwig cross-coupling reactions.
• To synthesize highly regioselective aryl fluorides by Pd-catalyzed fluorination of a variety of activated aryl and heteroaryl triflates and bromides.
• To prepare aryl thioethers by C–S cross-coupling of thiols with aromatic electrophile in the presence of palladium catalyst.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3