906298

3-(4-Bromophenyl)-3-(trifluoromethyl)-3H-diazirine

• Synonyme(s) : Probe building block for photoaffinity labeling, Suzuki-Miyaura-compatible multifunctional photo probe building block, Trifluoromethyl diazirine aryl bromide
• Formule empirique (notation de Hill) : C₈H₄BrF₃N₂
• CAS Number: 952143-02-1
• Poids moléculaire : 265.03
• Numéro MDL: MFCD31667367
• Code UNSPSC : 12352101
• Nomenclature NACRES : NA.22

Propriétés

• Essai: ≥95%
• Forme: liquid
• Pertinence de la réaction: reagent type: cross-linking reagent
• Température de stockage: 2-8°C
• Chaîne SMILES: BrC1=CC=C(C2(N=N2)C(F)(F)F)C=C1
• InChI: 1S/C8H4BrF3N2/c9-6-3-1-5(2-4-6)7(13-14-7)8(10,11)12/h1-4H
• Clé InChI: YBEXZCGWGWNLQQ-UHFFFAOYSA-N

Description

Application

3-(4-Bromophenyl)-3-(trifluoromethyl)-3H-diazirine is a Suzuki-Miyaura (S−M)-compatible building block tailored for the design of photoaffinity probes (PAPs). Photoaffinity labeling (PAL) is of growing interest in chemical biology and drug discovery research for use in protein profiling; covalent inhibitors; protein-protein interactions and complexes; and target engagement, identification, or validation studies. Diazirines are desirable photoactivable groups for chemical probes; however, their installation is not always straightforward. In response, diazirine-tolerant S-M coupling conditions were developed by Ichiishi, et al, using 3-(4-bromophenyl)-3-(trifluoromethyl)-3H-diazirine and shown to be efficient and scalable with minimal perturbation of the diazirine.

Product can be used with our line of photoreactors: Including Penn PhD (Z744035) & SynLED 2.0 (Z744080)

Autres remarques

Reducing Limitation in Probe Design: The Development of a Diazirine-Compatible Suzuki-Miyaura Cross Coupling Reaction

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable