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MilliporeSigma
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Principaux documents

935824

Sigma-Aldrich

Polyester-based biodegradable bioink

suitable for extrusion-based 3D bioprinting

Synonyme(s) :

SOLID INX

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About This Item

Code UNSPSC :
12352200

Niveau de qualité

100

Forme

solid

Couleur

off-white

Viscosité

10-30 Pa.s

Pf

40-60 °C

Résistance du gel

(Young′s modulus after UV crosslinking (Mpa) 150-200)

Description générale

The polyester-based biodegradable bioink is a photocrosslinkable, hydrophobic, and biocompatible bioink that combines the benefits of conventional stiff polyester materials with low temperature (<65°C) processability. This bioink has been used to generate and sustain 3D cellular structures of a variety of human tissues including cartilage (chondrocytes), blood vessels (HUVECs), smooh muscle cells (SMCs), and skin (HFFs).

Properties and Processing: The polyester-based biodegradable bioink is provided in a ready to print cartridge and is a semi-crystalline solid at room temperature with a melting emperature around 50°C and crystallization temperature of 25°C and displays Newtonian fluidic characteristics. The visocity of the bioink makes it suitable for an easy extrusion from the nozzlee during printing, resulting in a printable formulation in pneumatic 3D printers operating at pressures between 80-160 kPa. The ink is in molten state in the dispenser (~60°C), after which the printed constructs are solidified as a result of rapid cystrallization. The printed scaffold can then crosslinked via UV light.

Application

3D bioprinting
Tissue engineering
In vitro modeling

Caractéristiques et avantages

  • Easy printing - The bioink can be processed at low temperatures followed by photocrosslinking, making it ideal for hybrid scaffolds
  • Biocompatibility - Exceptional biocompatibility and no contact toxicity
  • Biodegradable - Fully biodegradable materials allows cellular remodeling of printed matrix
  • Easy handling - Delivered in a ready-to-use cartridge, ready to print after heating
  • UV curable - Efficient UV-based crosslinking
  • Reproducibility - Strict quality control
  • Mechanical integrity - Robust yet flexible polymer suitable for stiffer tissue engineering applications

Produit(s) apparenté(s)

Réf. du produit
Description
Tarif

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Lot/Batch Number

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