D4407

2-Deoxy-D-galactose

98%

• Synonyme(s) : 2-Deoxy-D-lyxohexose
• Formule empirique (notation de Hill) : C₆H₁₂O₅
• CAS Number: 1949-89-9
• Poids moléculaire : 164.16
• Beilstein: 1723333
• Numéro CE : 217-765-3
• Numéro MDL: MFCD00014649
• Code UNSPSC : 12352201
• ID de substance PubChem : 24893869
• Nomenclature NACRES : NA.22

Propriétés

• Niveau de qualité: 200
• Essai: 98%
• Forme: powder
• Activité optique: [α]20/D +59.7°, c = 2 in H₂O
• Couleur: white to off-white
• Pf: 107 - 110 °C ((225 - 230 °F)); 107-110 °C (lit.)
• Chaîne SMILES: OC[C@H]1OC(O)C[C@@H](O)[C@H]1O
• InChI: 1S/C6H12O5/c7-2-4-6(10)3(8)1-5(9)11-4/h3-10H,1-2H2/t3-,4-,5?,6-/m1/s1
• Clé InChI: PMMURAAUARKVCB-DUVQVXGLSA-N

Description

Description générale

2-Deoxy-D-galactose is a glucose analog that shows a wide range of biological activities such as inhibition of glycolysis and thereby tumor growth, interference with the biosynthetic processing of glycoproteins, antiviral activity, and hepatotoxicity. It is being extensively studied as trapping agents for phosphate and uridylate in mammalian cells due to its ability to interfere in the phosphate and nucleotide metabolism.

Application

• FUT1-mediated terminal fucosylation acts as a new target to attenuate renal fibrosis.: This research investigates the role of 2-deoxy-D-galactose in modulating terminal fucosylation processes, revealing potential therapeutic pathways for treating renal fibrosis and enhancing the understanding of kidney disease mechanisms (Luo et al., 2023).


• 2-D-gal Targets Terminal Fucosylation to Inhibit T-cell Response in a Mouse Skin Transplant Model.: Highlights the immunomodulatory potential of 2-deoxy-D-galactose in transplant medicine, showing how it can inhibit T-cell responses and contribute to the success of skin grafts, pointing towards new immunosuppressive treatments (Mao et al., 2023).


• Inhibition of Aberrant α(1,2)-Fucosylation at Ocular Surface Ameliorates Dry Eye Disease.: Explores the therapeutic effects of 2-deoxy-D-galactose in treating dry eye disease by modulating specific fucosylation pathways, potentially opening new avenues for ocular surface treatment strategies (Yoon et al., 2021).

Autres remarques

To gain a comprehensive understanding of our extensive range of Monosaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)