D97754

Diethyl malonate

ReagentPlus^®, 99%

• Synonyme(s) : Malonic acid diethyl ester
• Formule linéaire : CH₂(COOC₂H₅)₂
• CAS Number: 105-53-3
• Poids moléculaire : 160.17
• Beilstein: 774687
• Numéro CE : 203-305-9
• Numéro MDL: MFCD00009195
• Code UNSPSC : 12352100
• ID de substance PubChem : 24894329
• Nomenclature NACRES : NA.22

Propriétés

• Densité de vapeur: 5.52 (vs air)
• Niveau de qualité: 200
• Pression de vapeur: 1 mmHg ( 40 °C)
• Gamme de produits: ReagentPlus^®
• Essai: 99%
• Forme: liquid
• Indice de réfraction: n20/D 1.413 (lit.)
• pb: 199 °C (lit.)
• Pf: −51-−50 °C (lit.)
• Densité: 1.055 g/mL at 25 °C (lit.)
• Chaîne SMILES: CCOC(=O)CC(=O)OCC
• InChI: 1S/C7H12O4/c1-3-10-6(8)5-7(9)11-4-2/h3-5H2,1-2H3
• Clé InChI: IYXGSMUGOJNHAZ-UHFFFAOYSA-N

Description

Description générale

Diethyl malonate is diethyl ester of malonic acid. It is widely used as a versatile building block for introducing the malonate functional group into molecules. Acylation of diethyl malonate using magnesium chloride and triethylamine is reported. K₂CO₃-catalyzed 1,4-addition reaction of diethyl malonate with various substituted 1,2-allenic ketones yields polyfunctionalized β,γ-unsaturated enones.

Application

Diethyl malonate was used to investigate Knoevenagel condensation reactions in microreactor using zeolite catalysts obtained by grafting amino groups onto NaX and CsNaX zeolites. It may be used in the synthesis of diethyl benzylidenemalonate by base catalyzed Knoevenagel condensation with benzaldehyde. It may be used in the synthesis of α-aryl malonates.

Conditionnement

Packaged in glass bottles

Informations légales

ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H319
• Conseils de prudence: P264 - P280 - P305 + P351 + P338 - P337 + P313
• Classification des risques: Eye Irrit. 2
• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): 199.4 °F - closed cup
• Point d'éclair (°C): 93 °C - closed cup
• Équipement de protection individuelle: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)