P2139

Poly(éthylène glycol)

average M_N 8,000, hydroxyl

• Synonyme(s) : PEG
• Formule linéaire : H(OCH₂CH₂)_nOH
• CAS Number: 25322-68-3
• Numéro MDL: MFCD00081839
• Code UNSPSC : 12352104
• ID de substance PubChem : 24898275
• Nomenclature NACRES : NA.23

Propriétés

• Product Name: Poly(éthylène glycol), average mol wt 8,000, powder
• Forme: powder
• Niveau de qualité: 200
• Poids mol.: average mol wt 8,000
• Solubilité: water: soluble (PEG is soluble in water approximately 630 mg/ml, 20 °C)
• Densité: 1.0845 g/mL at 70 °C; 1.0689 g/mL at 90 °C
• Extrémité Ω: hydroxyl
• Extrémité α: hydroxyl
• Chaîne SMILES: C(CO)O
• InChI: 1S/C2H6O2/c3-1-2-4/h3-4H,1-2H2
• Clé InChI: LYCAIKOWRPUZTN-UHFFFAOYSA-N

Description

Description générale

Polyethylene glycol (PEG) is a hydrophilic polymer. It can be easily synthesized by the anionic ring opening polymerization of ethylene oxide, into a range molecular weights and variety of end groups. When crosslinked into networks PEG can have high water content, forming “hydrogels”. PEG is a suitable material for biological applications because it does not trigger an immune response

Application

Poly (ethylene glycol) can be used in the formulation of the drug to improve its dissolution rate and oral bioavailability.

PEG can be used for the effective isolation of edible nanoparticles (ENPs) which have excellent anti-cancer and anti-inflammatory activities. PEG is a crowding agent and forms a net-like mesh in which nanovesicles are trapped and precipitated. For example, ginger-derived ENPs are isolated using a PEG-based method which is cost-effective compared to ultracentrifugation.

PEG can be used as a precursor to synthesize degradable hydrogels for the controlled release of hydrophilic and high molecular weight pharmaceuticals.

Caractéristiques et avantages

• Highstructural flexibility
• Biocompatibility
• Amphiphilicity
• Highhydration capacity
• Devoidof any steric hindrance

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)