700046P

7-ketocholesterol-d7

Avanti Research^™ - A Croda Brand

• Synonyme(s) : 3b-hydroxy-5-cholestene-7-one(d7); 7-Oxocholesterol(d7); 7-oxo-5-Cholesten-3b-ol-7-one(d7); 5-cholesten-3 b-ol-7-one(d7); 3b-Hydroxycholest-5-en-7-one(d7)
• Formule empirique (notation de Hill) : C₂₇H₃₇O₂D₇
• CAS Number: 127684-08-6
• Poids moléculaire : 407.68
• Numéro MDL: MFCD06658677
• Code UNSPSC : 12352100
• Nomenclature NACRES : NA.25

Propriétés

• Description: 3β-hydroxy-5-cholestene-7-one-d7
• Essai: >99% (TLC)
• Forme: powder
• Conditionnement: pkg of 1 × 1 mg (700046P-1mg); pkg of 1 × 5 mg (700046P-5mg)
• Fabricant/nom de marque: Avanti Research^™ - A Croda Brand
• Conditions d'expédition: dry ice
• Température de stockage: −20°C
• Chaîne SMILES: O[C@H]1CC[C@@]2([C@@H]3[C@H]([C@H]4[C@@](C(CC4)[C@@H](CCCC(C([2H])([2H])[2H])(C([2H])([2H])[2H])[2H])C)(CC3)C)C(=O)C=C2C1)C
• InChI: 1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h16-18,20-23,25,28H,6-15H2,1-5H3/t18-,20+,21?,22+,23+,25+,26+,27-/m1/s1/i1D3,2D3,17D
• Clé InChI: YIKKMWSQVKJCOP-YMQSFMNJSA-N

Description

Description générale

7-ketocholesterol-d7 is a deuterated derivative of 7-ketocholesterol. 7-ketocholesterol is a cholesterol autooxidation product.

Application

7-ketocholesterol-d7 has been used:

• as a deuterated internal standard for spiking plasma samples for liquid chromatography with tandem mass spectrometry (LC-MS-MS) analysis
• as a deuterated internal standard for spiking aorta and macrophage lipid extract gas chromatography-mass spectrometry (CG/MS)
• as an internal standard in ultra performance liquid chromatography - tandem mass spectrometer (UPLC-MS/MS) for plasma oxysterol analysis

Actions biochimiques/physiologiques

7-ketocholesterol (7-KC) levels are elevated in cerebrospinal fluid in multiple sclerosis, senile cataracts, in erythrocytes of sickle cell anemia and in hypercholesterolemia. 7-KC favors apoptosis in macrophages and is involved in endoplasmic reticulum stress. 7-KC is also implicated in liver damage and Niemann Pick disease.

Conditionnement

5 mL Amber Glass Screw Cap Vial (700046P-1mg)

5 mL Amber Glass Screw Cap Vial (700046P-5mg)

Informations légales

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids