700060P

desmosterol

Avanti Research^™ - A Croda Brand

• Synonyme(s) : 24-dehydrocholesterol; 5,24-cholestadien-3β-ol; 110798
• Formule empirique (notation de Hill) : C₂₇H₄₄O
• CAS Number: 313-04-2
• Poids moléculaire : 384.64
• Numéro MDL: MFCD00056432
• Code UNSPSC : 12352211
• Nomenclature NACRES : NA.25

Propriétés

• Description: 3β-hydroxy-5,24-cholestadiene
• Essai: >99% (TLC)
• Forme: powder
• Conditionnement: pkg of 1 × 10 mg (700060P-10mg); pkg of 1 × 5 mg (700060P-5mg)
• Fabricant/nom de marque: Avanti Research^™ - A Croda Brand
• Conditions d'expédition: dry ice
• Température de stockage: −20°C
• Chaîne SMILES: O[C@H]1CC[C@@]2([C@@H]3[C@H]([C@H]4[C@@]([C@H](CC4)[C@@H](CCC=C(C)C)C)(CC3)C)CC=C2C1)C
• InChI: 1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,9,19,21-25,28H,6,8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
• Clé InChI: AVSXSVCZWQODGV-DPAQBDIFSA-N

Description

Description générale

Desmosterol lacks a double bond between C24 and C25 compared to cholesterol. It is present in the membrane of spermatozoa and astrocytes and is the major brain sterol.

Application

Desmosterol has been used as a sterol to test its interaction with human protein Mincle and as an internal standard in ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS). It may be used as in the preparation of lipid monolayers.

Actions biochimiques/physiologiques

Desmosterol is a precursor of cholesterol in the Bloch pathway and the enzyme 24-dehydrocholesterol reductase catalyzes this step. Desmosterol accumulates during impairment of 24-dehydrocholesterol reductase enzyme thereby leading to desmosterolosis. Desmosterol is a liver X receptor (LXR) agonist . It is a potential therapeutic target for treating the neurodegenerative disorder. Desmosterol regulates inflammatory signaling in macrophages.

Conditionnement

5 mL Amber Glass Screw Cap Vial (700060P-10mg)

5 mL Amber Glass Screw Cap Vial (700060P-5mg)

Informations légales

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable