810205X

NBD Sphingosine

omega(7-nitro-2-1,3-benzoxadiazol-4-yl)(2S,3R,4E)-2-aminooctadec-4-ene-1,3-diol, chloroform:methanol (8:2)

• Synonyme(s) : D-erythro-Sphingosine-N-NBD
• Formule empirique (notation de Hill) : C₂₄H₃₉N₅O₅
• CAS Number: 799268-47-6
• Poids moléculaire : 477.60
• Numéro MDL: MFCD00870345
• Code UNSPSC : 12352211
• Nomenclature NACRES : NA.25

Propriétés

• Essai: >99% (TLC)
• Forme: liquid
• Conditionnement: pkg of 1 × 1 mL (810205X-250ug)
• Fabricant/nom de marque: Avanti Research^™ - A Croda Brand 810205X
• Concentration: 0.25 mg/mL (810205X-250ug)
• Conditions d'expédition: dry ice
• Température de stockage: −20°C

Description

Description générale

Sphingosine is the most bioactive sphingoid with the common long chain base in sphingolipids. It is a constituent of the cell membrane. 7-nitro-2-1,3-benzoxadiazol-4-yl (NBD) sphingosine is a derivative of sphingosine attached with the fluorescent probe, NBD group.

Application

NBD Sphingosine or omega(7-nitro-2-1,3-benzoxadiazol-4-yl)(2S,3R,4E)-2-aminooctadec-4-ene-1,3-diol may be used:

• as a negative control to determine the binding of Atg12-Atg5 conjugate with phosphatidylethanolamine (PE)-containing liposomes
• to label sphingosine kinase 1 (SphK1) in order to determine its role in endocytic membrane trafficking
• to generate 7-nitrobenz-2-oxa-1,3-diazol-4-yl (NBD)-ceramide C16

Actions biochimiques/physiologiques

Sphingosine serves as a precursor for ceramide. It is involved in the inhibition of protein kinase C in human platelets.

Conditionnement

5 mL Amber Glass Screw Cap Vial (810205X-250ug)

Informations légales

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Informations sur la sécurité

• Pictogrammes: GHS06,GHS08
• Mention d'avertissement: Danger
• Mentions de danger: H302 + H312,H315,H319,H331,H336,H351,H361d,H370,H372
• Conseils de prudence: P260 - P280 - P304 + P340 + P311 - P305 + P351 + P338 - P308 + P311 - P403 + P233
• Classification des risques: Acute Tox. 3 Inhalation - Acute Tox. 4 Dermal - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 1 - STOT SE 3
• Organes cibles: Central nervous system
• Code de la classe de stockage: 3 - Flammable liquids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): >125.5 °F
• Point d'éclair (°C): > 51.95 °C