857371P

VU0359595

(1R,2R)-N-([S]-1-{4-[5-bromo-2-oxo-2,3-dihydro-1H-benzo(d)imidazol-1-yl]piperidin-1-yl}propan-2-yl)-2-phenylcyclopropanecarboxamide, powder

• Synonyme(s) : EVJ; VU0359595
• Formule empirique (notation de Hill) : C₂₅H₂₉BrN₄O₂
• CAS Number: 1246303-14-9
• Poids moléculaire : 497.43
• Numéro MDL: MFCD22416858
• Code UNSPSC : 12352211
• Nomenclature NACRES : NA.25

Propriétés

• Essai: >99% (TLC)
• Forme: powder
• Conditionnement: pkg of 1 × 1 mg (857371P-1mg)
• Fabricant/nom de marque: Avanti Research^™ - A Croda Brand 857371P
• Type de lipide: bioactive lipids
• Conditions d'expédition: dry ice
• Température de stockage: −20°C
• Chaîne SMILES: Brc1cc2[nH][c]([n](c2cc1)C3CCN(CC3)C[C@@H](NC(=O)[C@H]4[C@@H](C4)c5ccccc5)C)=O
• Clé InChI: JSVNNLRZCJAYTQ-ORYQWCPZSA-N

Description

Description générale

VU0359595 has been shown to selectively inhibit the PLD1 isoform at nM levels (see data below). **Images added as .gif in folder

Application

VU0359595 has been used as PLD2 (phospholipase D2) inhibitor to quantitatively address functional and molecular aspects of the involvement of PLD-derived phosphatidic acid (PA) in regulated exocytosis and as PLD1 inhibitor to treat the knockout mice to study its effects on them.

Actions biochimiques/physiologiques

VU0359595 helps to block phospholipase D (PLD) which in turn reduces deoxyribonucleoside triphosphate (dNTP) biosynthesis in glioma models.

Conditionnement

5 mL Amber Glass Screw Cap Vial (857371P-1mg)

Informations légales

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable