860462P

N-C16-deoxysphinganine

N-palmitoyl-1-deoxysphinganine (m18:0/16:0), powder

• Synonyme(s) : N-hexadecanoyl-1-deoxysphinganine (m18:0/16:0); N-C16-1-deoxyDHCer; 110960
• Formule empirique (notation de Hill) : C₃₄H₆₉NO₂
• CAS Number: 378755-69-2
• Poids moléculaire : 523.92
• Numéro MDL: MFCD00152125
• Code UNSPSC : 12352211
• Nomenclature NACRES : NA.25

Propriétés

• Essai: >99% (TLC)
• Forme: powder
• Conditionnement: pkg of 1 × 1 mg (860462P-1mg); pkg of 1 × 5 mg (860462P-5mg)
• Fabricant/nom de marque: Avanti Research^™ - A Croda Brand 860462P
• Type de lipide: sphingolipids; bioactive lipids
• Conditions d'expédition: dry ice
• Température de stockage: −20°C

Description

Description générale

Commonly referred to as 1-deoxydihydroceramide (1-deoxyDHCer), this product is the N-acylated form of 1-deoxysphinganine, a potent inhibitor of sphingolipid metabolism. The biological activity of 1-deoxyDHCer is not clearly understood at this time.

N-C16-deoxysphinganine Commonly referred to as 1-deoxydihydroceramide (1-deoxyDHCer), is the N-acylated form of 1-deoxysphinganine, a potent inhibitor of sphingolipid metabolism. The N-acyl group can be 16, 20 and 24 carbon chain. N-acylsphinganines (dihydroceramides) are synthesized by the acylation of sphingoid bases in the presence of ceramide synthases (CerS).

Actions biochimiques/physiologiques

N-acylsphinganines (dihydroceramides) levels are lower during ceramide synthase inhibition. They are intermediates of ceramide and dihydrosphingolipids synthesis. Treatment of MCF7 cancer cells with fenretinide alters sphingolipid metabolism.

Conditionnement

5 mL Amber Glass Screw Cap Vial (860462P-1mg)

5 mL Amber Glass Screw Cap Vial (860462P-5mg)

Informations légales

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3