860539P

C16 Glucosyl(β) Ceramide (d18:1/16:0)

Avanti Research^™ - A Croda Brand

• Synonyme(s) : D-glucosyl-β-1,1′-N-palmitoyl-D-erythro-sphingosine
• Formule empirique (notation de Hill) : C₄₀H₇₇NO₈
• CAS Number: 74365-77-8
• Poids moléculaire : 700.04
• Numéro MDL: MFCD22416657
• Code UNSPSC : 12352211
• Nomenclature NACRES : NA.25

Propriétés

• Forme: powder
• Conditionnement: pkg of 1 × 25 mg (860539P-25mg); pkg of 1 × 5 mg (860539P-5mg)
• Fabricant/nom de marque: Avanti Research^™ - A Croda Brand
• Type de lipide: sphingolipids
• Conditions d'expédition: dry ice
• Température de stockage: −20°C
• Chaîne SMILES: [H][C@](/C=C/CCCCCCCCCCCCC)(O)[C@@]([H])(NC(CCCCCCCCCCCCCCC)=O)CO[C@H](O1)[C@H](O)[C@@H](O)[C@@H]([C@H]1CO)O
• Clé InChI: VJLLLMIZEJJZTE-NNTBDIJYSA-N

Description

Description générale

Glucosyl(β) Ceramide (β-GlcCer) is a naturally occurring glycolipid and an ubiquitous intracellular metabolite. It might be present in the endoplasmic reticulum or Golgi apparatus.

Application

C16 Glucosyl(β) Ceramide (d18:1/16:0) or D-glucosyl-β-1,1′-N-palmitoyl-D-erythro-sphingosine has been used as a stock solution for the in vitro treatment of bacteria and to study the role of sphingolipids on pulmonary Pseudomonas aeruginosa infections in cystic fibrosis (CF). It may be used in the quantification of lipid in green fluorescence protein (GFP) and fatty acid transport protein 4 (FATP4) cells using electrospray ionization tandem mass spectrometry (ESI-MS/MS).

Actions biochimiques/physiologiques

Glucosyl(β) Ceramide (β-GlcCer) is an endogenous macrophage inducible C-type lectin (Mincle) ligand, which has immunostimulatory property. It also stimulates inflammatory and acquired immune responses on myeloid cells through Mincle. It is a potential biomarker in Gaucher′s disease. β-GlcCer regulates the function of natural killer T (NKT) lymphocytes and exhibits antimetastatic effects. A balanced level of intracellular β-GlcCer is essential for maintaining tissue homeostasis.

Conditionnement

5 mL Amber Glass Screw Cap Vial (860539P-25mg)

5 mL Amber Glass Screw Cap Vial (860539P-5mg)

Informations légales

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids