890700P

12:0 EPC (Cl Salt)

Avanti Research^™ - A Croda Brand 890700P, powder

• Synonyme(s) : 1,2-dilauroyl-sn-glycero-3-ethylphosphocholine (chloride salt)
• Formule empirique (notation de Hill) : C₃₄H₆₉NO₈PCl
• CAS Number: 474945-22-7
• Poids moléculaire : 686.34
• Numéro MDL: MFCD22495356
• Code UNSPSC : 12352211
• Nomenclature NACRES : NA.25

Propriétés

• Forme: powder
• Conditionnement: pkg of 1 × 10 mg (890700P-10mg)
• Fabricant/nom de marque: Avanti Research^™ - A Croda Brand 890700P
• Type de lipide: cationic lipids; transfection
• Conditions d'expédition: dry ice
• Température de stockage: −20°C
• Chaîne SMILES: O=P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(CCCCCCCCCCC)=O)COC(CCCCCCCCCCC)=O)OCC.[Cl-]
• InChI: 1S/C34H69NO8P.ClH/c1-7-10-12-14-16-18-20-22-24-26-33(36)39-30-32(31-42-44(38,40-9-3)41-29-28-35(4,5)6)43-34(37)27-25-23-21-19-17-15-13-11-8-2;/h32H,7-31H2,1-6H3;1H/q+1;/p-1/t32-,44?;/m1./s1
• Clé InChI: QWVQEMZYQQUQCH-XFSYIJCRSA-M

Description

Description générale

1,2-dilauroyl-sn-glycero-3-ethylphosphocholine (12:0 EPC) is a cationic phospholipid. 12:0 EPC is a short-chain analog of dioleoyl ethylphosphatidylcholine. O-alkyl phosphatidylcholines constitute the first chemically stable triesters of biological lipid structures and the first cationic derivatives of phospholipids consisting entirely of biological metabolites linked with ester bonds. The lipid has low toxicity and is biodegradable.

Application

1,2-dilauroyl-sn-glycero-3-ethylphosphocholine (12:0 EPC (Cl Salt)) is suitable for use in lipoplex preparation and to study the lipoplex transfection activity. It might also be used in lipid mixtures to study its cubic phases of formation, stability and phase transitions.

Actions biochimiques/physiologiques

1,2-dilauroyl-sn-glycero-3-ethylphosphocholine (12:0 EPC) is preferred for transfection of cultured primary endothelial cells. 12:0 EPC forms lamellar lipoplexes possessing high to superior transfection activity. Chemically synthesized cationic lipids are applicable as non-viral gene carriers. Variation in the hydrocarbon chain of phosphatidylcholine (PC) derivatives affects transfection efficiency.

Conditionnement

5 mL Clear Glass Sealed Ampule (890700P-10mg)

Informations légales

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3