07-1497

Anti-cAMP Antibody

serum, from rabbit

• Code UNSPSC : 12352203
• eCl@ss : 32160702
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: rabbit
• Niveau de qualité: 100
• Forme d'anticorps: serum
• Type de produit anticorps: primary antibodies
• Clone: polyclonal
• Espèces réactives: rat
• Réactivité de l'espèce (prédite par homologie): all
• Technique(s): immunohistochemistry: suitable (paraffin)
• Conditions d'expédition: wet ice
• Modification post-traductionnelle de la cible: unmodified

Description

Description générale

Cyclic adenosine monophosphate or cAMP is an intracellular by-product of ATP by adenylene cyclase when G-protein Coupled Receptors (GPCR) bind various ligands on the cell surface. Cyclic AMP acts as a second messenger for signal transduction across the cell membrane and is a part of kinase activation. It regulates the effects of glucagon and adrenaline along with the movement of calcium ions through ion channels. Since it is affected directly by GPCR activation, cAMP is studied as a means to monitor GPCR in the discovery of therapeutic drugs.

Spécificité

Specific for cAMP with no cross reaction to other nucleotides at concentrations to 1 mM. Reactive with cAMP fixed in tissues or acetylated cAMP. Not reactive with free, non-acetylated, cAMP in RIA or EIA assays.

Immunogène

2′O-succinyl cyclic AMP conjugated to BSA

Application

Anti-cAMP Antibody detects level of cAMP & has been published & validated for use in IH(P).

Research Category
Signaling

Research Sub Category
GPCR, cAMP/cGMP & Calcium Signaling

Qualité

Evaluated by Immunohistochemistry in rat hippocampus and cerebellum tissue.
Immunohistochemistry Analysis: 1:100 dilution of this lot detected cAMP in rat hippocampus and cerebellum tissue.

Liaison

Replaces: MABN1026

Forme physique

Diluted serum presented as liquid in PBS containing no preservatives.

Unpurified rabbit serum

Stockage et stabilité

Maintain at -20°C in undiluted aliquots from date of shipment. Avoid repeated freeze/thaw cycles.

Remarque sur l'analyse

Control
Rat hippocampus and cerebellum tissue

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Code de la classe de stockage: 12 - Non Combustible Liquids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable