106425

N-Acetyl-L-cysteine

Mucolytic agent and thiol-based antioxidant that has a protective effect against oxygen free radicals in early septic shock.

• Synonyme(s) : N-Acetyl-L-cysteine, LNAC
• Formule empirique (notation de Hill) : C₅H₉NO₃S
• CAS Number: 616-91-1
• Poids moléculaire : 163.19
• Numéro MDL: MFCD00004880
• Code UNSPSC : 12352209
• Nomenclature NACRES : NA.25

Propriétés

• Description: Merck USA index - 14, 88
• Niveau de qualité: 200
• Essai: ≥98% (titration)
• Forme: solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze
• Couleur: white
• Solubilité: water: 50 mg/mL
• Traces d'anions: chloride (Cl^-): ≤0.04%; sulfate (SO₄^2-): ≤0.03%
• Traces de cations: Fe: ≤20 ppm
• Conditions d'expédition: ambient
• Température de stockage: 15-25°C
• Chaîne SMILES: SCC(NC(=O)C)C(=O)O
• InChI: 1S/C5H9NO3S/c1-3(7)6-4(2-10)5(8)9/h4,10H,2H2,1H3,(H,6,7)(H,8,9)
• Clé InChI: PWKSKIMOESPYIA-UHFFFAOYSA-N

Description

Description générale

A mucolytic agent and thio-based antioxidant. Increases the cellular pool of free-radical scavengers. Inhibits HIV replication. Prevents apoptotic death of neuronal cells. Antidote for acetaminophen poisoning. May serve as a substrate for microsomal glutathione transferase. Induces apoptosis in human and rat smooth muscle cells.

Mucolytic agent and thiol-based antioxidant that has a protective effect against oxygen free radicals in early septic shock. Increases cellular pools of free-radical scavengers. Inhibitor of HIV replication. May serve as a substrate for microsomal glutathione transferase. Induces apoptosis in human and rat smooth muscle cells.

Application

• Chlorpyrifos-induced suppression of the antioxidative defense system leads to cytotoxicity and genotoxicity in macrophages.: The study highlights the protective role of N-acetyl-L-cysteine against chlorpyrifos-induced oxidative damage in macrophages, emphasizing its importance in mitigating pesticide toxicity (Lu et al., 2024).


• N-Acetyl-L-Cysteine Attenuates Titanium Dioxide Nanoparticle (TiO2 NP)-Induced Autophagy in Male Germ Cells.: This research explores how N-acetyl-L-cysteine can mitigate the autophagic effects induced by titanium dioxide nanoparticles in male germ cells, suggesting its use in reproductive health (Shin et al., 2024).

Conditionnement

Packaged under inert gas

Avertissement

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution aliquot and freeze (-20°C). Aqueous stock solutions are stable for up to 1 month at -20°C.

Autres remarques

Ortolani, O., et al. 2000. Am. J. Respir. Crit. Care Med. 161, 1907.
Tsai, J.C., et al. 1996. J. Biol. Chem. 271, 3667.
Ferrari, G., et al. 1995. J. Neurosci.15, 2857.
Weinander, R., et al. 1994. J. Biol. Chem.269, 71.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H319
• Conseils de prudence: P264 - P280 - P305 + P351 + P338 - P337 + P313
• Classification des risques: Eye Irrit. 2
• Code de la classe de stockage: 13 - Non Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable