437720

Lipoxin A₄

Lipoxin A₄, CAS 89663-86-5, is a potent inhibitor of cytotoxic activity of human natural killer cells. Shown to be as potent as LTB4 in stimulating human neutrophils to generate superoxides.

• Synonyme(s) : Lipoxin A₄, LXA₄, 5(S),6(R),15(S)-Trihydroxyeicosa-7- trans-9- trans-11- cis-13- trans-tetraenoic Acid, LXA₄, 5(S),6(R),15(S)-Trihydroxyeicosa-7-trans-9-trans-11-cis-13-trans-tetraenoic Acid
• Formule empirique (notation de Hill) : C₂₀H₃₂O₅
• CAS Number: 89663-86-5
• Poids moléculaire : 352.47
• Numéro MDL: MFCD00065845
• Code UNSPSC : 12352211
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥95% (HPLC)
• Forme: liquid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze
• Solubilité: ethanol: soluble
• Conditions d'expédition: wet ice
• Température de stockage: −70°C
• Chaîne SMILES: O[C@H]([C@H](O)\C=C\C=C\C=C/C=C/[C@@H](O)CCCCC)CCCC(=O)O
• InChI: 1S/C20H32O5/c1-2-3-8-12-17(21)13-9-6-4-5-7-10-14-18(22)19(23)15-11-16-20(24)25/h4-7,9-10,13-14,17-19,21-23H,2-3,8,11-12,15-16H2,1H3,(H,24,25)/b6-4-,7-5+,13-9+,14-10+/t17-,18+,19-/m0/s1
• Clé InChI: IXAQOQZEOGMIQS-SSQFXEBMSA-N

Description

Description générale

Caution! Product contains volatile liquid. Keep product cold at all times.

Potent inhibitor of cytotoxic activity of human natural killer cells; shown to be as potent as LTB₄ in stimulating human neutrophils to generate superoxides. Involved in contractile responses and acts as a potent activator of human protein kinase C. Stimulates rapid lipid remodeling and pertussis-sensitive release of arachidonic acid in polymorphonuclear leukocytes. Stimulates MAP kinases via activation of G protein-coupled receptors.

Actions biochimiques/physiologiques

Cell permeable: no

Primary Target
Potent inhibitor of cytotoxic activity of human natural killer cells

Product does not compete with ATP.

Reversible: no

Avertissement

Toxicity: Flammable (J)

Forme physique

In Ethanol.

Reconstitution

Following initial thaw, aliquot and freeze (-70°C).

Autres remarques

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

McMahon, B., et al. 2000. J. Biol. Chem. 275, 27566.
Soyombo, O., et al. 1994. Allergy 49, 230.
Flore, S., et al. 1992. J. Biol. Chem.267, 16168.
Badr, K.F., et al. 1989. Proc. Natl. Acad. Sci. USA86, 3438.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Pictogrammes: GHS02,GHS07
• Mention d'avertissement: Danger
• Mentions de danger: H225,H319
• Conseils de prudence: P210 - P233 - P240 - P241 - P242 - P305 + P351 + P338
• Classification des risques: Eye Irrit. 2 - Flam. Liq. 2
• Code de la classe de stockage: 3 - Flammable liquids
• Classe de danger pour l'eau (WGK): WGK 2