475880

ML-7, Hydrochloride

A cell-permeable, potent, reversible, ATP-competitive, and selective inhibitor of myosin light chain kinase (K_i = 300 nM).

• Synonyme(s) : ML-7, Hydrochloride, 1-(5-Iodonaphthalene-1-sulfonyl)homopiperazine, HCl
• Formule empirique (notation de Hill) : C₁₅H₁₇IN₂O₂S · xHCl
• CAS Number: 110448-33-4
• Poids moléculaire : 416.28 (free base basis)
• Numéro MDL: MFCD00065524
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: >98% (TLC)
• Forme: solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; desiccated (hygroscopic); protect from light
• Couleur: white
• Solubilité: 50% ethanol: 4.5 mg/mL; DMSO: 4.5 mg/mL
• Conditions d'expédition: ambient
• Température de stockage: 2-8°C
• Chaîne SMILES: Ic1c2c(c(ccc2)[S](=O)(=O)N3CCNCCC3)ccc1
• InChI: 1S/C15H17IN2O2S/c16-14-6-1-5-13-12(14)4-2-7-15(13)21(19,20)18-10-3-8-17-9-11-18/h1-2,4-7,17H,3,8-11H2
• Clé InChI: GEHJIACZUFWBTK-UHFFFAOYSA-N

Description

Description générale

A cell-permeable, potent, reversible, ATP-competitive, and selective inhibitor of myosin light chain kinase (K_i = 300 nM). Inhibits protein kinase A (K_i = 21 µM)and protein kinase C (K_i = 42 µM) at much higher concentrations.

Actions biochimiques/physiologiques

Cell permeable: yes

Primary Target
Myosin light chain kinase (Mlck)

Product competes with ATP.

Reversible: yes

Target K_i: 300 nM against myosin light chain kinase

Avertissement

Toxicity: Standard Handling (A)

Notes préparatoires

Further dilute with aqueous buffer just prior to use.

Reconstitution

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.

Autres remarques

Krarup, T., et al. 1998. Am. J. Physiol. 275, C239.
Saitoh, M., et al. 1987. J. Biol. Chem.262, 7796.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable