52332

Phenylmethylsulfonyl Fluoride

Phenylmethylsulfonyl Fluoride, CAS 329-98-6, is an irreversible inhibitor of serine proteases. It causes sulfonylation of the active-site serine residues.

• Synonyme(s) : Phenylmethylsulfonyl Fluoride, Benzylsulfonyl Fluoride, PMSF
• Formule empirique (notation de Hill) : C₇H₇FO₂S
• CAS Number: 329-98-6
• Poids moléculaire : 174.19
• Numéro MDL: MFCD00007424
• Code UNSPSC : 12352202
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 200
• Description: RTECS - XT8040000
• Essai: ≥99% (GC)
• Forme: crystalline solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; desiccated
• Couleur: white to off-white
• Solubilité: ethanol: soluble; isopropanol: soluble; methanol: soluble
• Conditions d'expédition: ambient
• Température de stockage: 10-30°C
• Chaîne SMILES: F[S](=O)(=O)Cc1ccccc1
• InChI: 1S/C7H7FO2S/c8-11(9,10)6-7-4-2-1-3-5-7/h1-5H,6H2
• Clé InChI: YBYRMVIVWMBXKQ-UHFFFAOYSA-N

Description

Description générale

Irreversible inhibitor of serine proteases. Its mechanism of action is analogous to that of diisopropylfluorophosphate. PMSF causes sulfonylation of the active-site serine residues. Also reported to inhibit internucleosomal DNA fragmentation in immature thymocytes. For a related, more stable inhibitor, see AEBSF (Cat. No. 101500).

Actions biochimiques/physiologiques

Cell permeable: no

Primary Target
serine proteases

Product does not compete with ATP.

Reversible: no

Avertissement

Toxicity: Corrosive (L)

Reconstitution

Following reconstitution, refrigerate (4°C). Stock solutions are stable for up to 9 months at 4°C.

t_½ = 1 hour at pH 7.5. Effective concentration: 50 μM.

Autres remarques

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Seitz, R., et al. 1993. Int. J. Cancer53, 514.
Weaver, V.M., et al. 1993. Biochem. Cell. Biol.71, 488.
Bourgain, R.H., et al. 1992. Adv. Exp. Med. Biol.316, 427.
Chang, C.T., et al. 1992. Biochem. Int.28, 707.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Pictogrammes: GHS06,GHS05
• Mention d'avertissement: Danger
• Mentions de danger: H301,H314
• Conseils de prudence: P260 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P363
• Classification des risques: Acute Tox. 3 Oral - Skin Corr. 1B
• Code de la classe de stockage: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable