580549

Tauroursodeoxycholic Acid, Sodium Salt

Tauroursodeoxycholic is a detergent useful for the solubilization of lipids and membrane-bound proteins.

• Synonyme(s) : Tauroursodeoxycholic Acid, Sodium Salt, Sodium Tauroursodeoxycholate
• Formule empirique (notation de Hill) : C₂₆H₄₄NO₆S · Na
• CAS Number: 35807-85-3
• Poids moléculaire : 521.69
• Numéro MDL: MFCD31725069
• Code UNSPSC : 12352106
• Nomenclature NACRES : NA.21

Propriétés

• Description: RTECS - KI7372500
• Niveau de qualité: 100
• Essai: ≥97% (TLC)
• Forme: solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze
• Couleur: white
• Solubilité: water: 100 mg/mL
• Conditions d'expédition: ambient
• Température de stockage: 15-25°C
• Chaîne SMILES: [S](=O)(=O)(O)CCNC(=O)CC[C@H]([C@@H]1[C@@]2(C(C3[C@H](C[C@H]4[C@@](C3CC2)(CC[C@H](C4)O)C)O)CC1)C)C
• InChI: 1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/t16-,17+,18-,19-,20?,21?,22+,24?,25+,26-/m1/s1
• Clé InChI: BHTRKEVKTKCXOH-AYSJQVDDSA-N

Description

Description générale

Detergent useful for the solubilization of lipids and membrane-bound proteins. Has cryoprotective effects against hydrophobic bile salts in rats. Also reported to inhibit pepsin activity in vitro.

Application

• Inhibition of endoplasmic reticulum stress combined with activation of angiotensin-converting enzyme 2: novel approach for the prevention of endothelial dysfunction in type 1 diabetic rats.: This study highlights the efficacy of tauroursodeoxycholic acid, sodium salt in reducing endoplasmic reticulum stress, suggesting its utility in preventing vascular complications in diabetes (Gaikwad AB et al., 2022).

Avertissement

Toxicity: Standard Handling (A)

Autres remarques

Ozcan, U., et al. 2006. Science313, 1137.
Miyake, H., et al. 1999. Dig. Dis. Sci.44, 197.
Eto, T. and Tompkins, R.K. 1985. Am. J. Surg.150, 564.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable