MAB1820

Anti-Scribble Antibody

clone 7C6.D10, Chemicon^®, from mouse

• Synonyme(s) : Scrib, LAP4
• Code UNSPSC : 12352203
• eCl@ss : 32160702
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: mouse
• Niveau de qualité: 100
• Forme d'anticorps: purified antibody
• Type de produit anticorps: primary antibodies
• Clone: 7C6.D10, monoclonal
• Espèces réactives: human
• Fabricant/nom de marque: Chemicon^®
• Technique(s): western blot: suitable
• Isotype: IgG1κ
• Numéro d'accès GenBank: AAL38976
• Numéro d'accès UniProt: Q14160
• Conditions d'expédition: wet ice
• Modification post-traductionnelle de la cible: unmodified
• Informations sur le gène: human ... SCRIB(23513)

Description

Description générale

Scribble is a tumor suppressor marker first discovered in Drosophila that has been implicated in the control of cell proliferation, polarity, invasion, and metastasis (Humbert, et al, 2003). Mammalian Scribble expresses basolateral staining in epithelial tissue and highly polarized expression in T lymphocytes (Dow, et al, 2003) (Ludford-Menting, et al, 2005), and plays an essential role in the regulation of the polarity specifically involved in directed epithelial migration. Altered expression of human Scribble is associated with invasive epithelial cancers, however, its role in tumour development remains unclear (Dow, et al, 2007).

Spécificité

Predicted to cross react with mouse based on sequence homology. Reactivity with other species has not been tested.

Immunogène

Epitope: PDZ2 domain of Scribble

GST-tagged fusion protein corresponding to the PDZ2 domain of Scribble

Application

Suggested dilutions:
Western blot: 0.2 µg (1:2000)

Research Sub Category
Tumor Markers

Cytoskeleton

This Anti-Scribble Antibody is validated for use in WB for the detection of Scribble.

Qualité

Routinely evaluated by Western blot on HeLa cell lysates.

Description de la cible

220 kDa

Forme physique

Format: Purified

Purified in PBS containing with 0.05% NaN3.

Stockage et stabilité

Maintain at 2-8°C for up to 1 year after date of receipt.

Autres remarques

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Informations légales

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

GenBank is a registered trademark of United States Department of Health and Human Services

Informations sur la sécurité

• Code de la classe de stockage: 12 - Non Combustible Liquids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable