Accéder au contenu
MilliporeSigma

Passer à

MABF422

Sigma-Aldrich

Anti-CD4 Antibody (human), APC-Cy7, clone RPA-T4

clone RPA-T4, from mouse

Synonyme(s) :

T-cell surface glycoprotein CD4, T-cell surface antigen T4/Leu-3, CD antigen CD4

Se connecterpour consulter vos tarifs contractuels et ceux de votre entreprise/organisme

Sélectionner une taille de conditionnement

24 X 500 ML
969,00 $

969,00 $


Veuillez contacter notre Service Clients pour connaître la disponibilité de ce produit.

Demander une commande groupée

Sélectionner une taille de conditionnement

Changer de vue
24 X 500 ML
969,00 $

About This Item

Code UNSPSC :
12352203
eCl@ss :
32160702
Nomenclature NACRES :
NA.44

969,00 $


Veuillez contacter notre Service Clients pour connaître la disponibilité de ce produit.

Demander une commande groupée
Service technique
Besoin d'aide ? Notre équipe de scientifiques expérimentés est là pour vous.
Laissez-nous vous aider

Source biologique

mouse

Niveau de qualité

Conjugué

APC-Cy7

Forme d'anticorps

purified antibody

Type de produit anticorps

primary antibodies

Clone

RPA-T4, monoclonal

Espèces réactives

human

Conditionnement

pkg of 5 μL (0.5 μg/test)

Technique(s)

flow cytometry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable

Isotype

IgG1κ

Comparer avec des articles similaires

Voir la comparaison complète

Montrer les différences

1 of 4

Cet article
EPU9430-0000EPK0641-3005EP6001061510
manufacturer/tradename

Eppendorf® U9420-0000

manufacturer/tradename

Eppendorf® U9430-0000

manufacturer/tradename

Eppendorf® K0641-3005 (Global)

manufacturer/tradename

Eppendorf® 6001061510 (Global)

parameter

ambient– -85 °C temp. range (pull down is 3.7 hours)

parameter

ambient– -85 °C temp. range (pull down is 5.3 hours)

parameter

-

parameter

-

feature

CE compliant

feature

CE compliant, CSA approved, 12 max. racks per freezer, with 3 shelves

feature

(2 x 2) configuration, Holds 4 x 102 mm/ 4 in boxes, drawer, max. box number per rack: 4 (2 x 2), rack for 102 mm/ 4 in boxes

feature

(4 x 2) configuration, Holds 8 x 127 mm/5 in boxes, max. box number per rack: 4 (2 x 2), max. box size [mm]: 136 x 136, side access

technique(s)

cryopreservation: suitable

technique(s)

cryopreservation: suitable

technique(s)

cryopreservation: suitable

technique(s)

cryopreservation: suitable

W × D × H

90 × 56.6 × 109.2 cm

W × D × H

80 × 86.7 × 195 cm

W × D × H

-

W × D × H

-

weight

116 kg

weight

250 kg

weight

-

weight

-

Description générale

The RPA-T4 antibody reacts with human CD4, a 59 kDa protein which acts as a co-receptor for the T cell receptor (TCR) in its interaction with MHC Class II molecules on antigen-presenting cells. The extracellular domain of CD4 binds to the beta-2 domain of MHC Class II, while its cytoplasmic tail provides a binding site for the tyrosine kinase lck, facilitating the signaling cascade that initiates T cell activation. CD4, and co-receptors CCR5 and CXCR4, may also be utilized by HIV-1 to enter T cells. Human CD4 is typically expressed on thymocytes, some mature T cell populations such as Th17 and T regulatory (Treg) cells, as well as on dendritic cells.The RPA-T4 antibody is widely used as a phenotypic marker for human CD4 expression, and is cross-reactive with Chimpanzee CD4. This antibody recognizes a different epitope, and thus does not block binding of, the alternative Anti-Human CD4 antibody clone OKT4 (Reinherz EL, et al. 1979. Proc. Natl. Acad. Sci. 76:4061-4065).

Immunogène

Immunogen information for this antibody is proprietary information.

Application

Research Category
Inflammation & Immunology
This mouse monoclonal antibody Anti-CD4 (human), APC-Cy7, clone RPA-T4 validated for use in IP, IHC & Flow Cytometry for the detection of CD4.

Qualité

The monoclonal antibody was purified from tissue culture supernatant via affinity chromatography. The purified antibody was conjugated under optimal conditions, with unreacted dye removed from the preparation.

Flow Cytometry Analysis: 0.5 μg of this antibody detected CD4 in one million human peripheral blood lymphocytes.

Forme physique

Purified Mouse Monoclonal Antibody in buffer containing 10 mM NaH2PO4, 150 mM NaCl, 0.1% gelatin, pH 7.2, and up to 0.1% sodium azide.
Size Exclusion Chromatography

Stockage et stabilité

It is recommended to store the product undiluted at 2-8°C and protected from prolonged exposure to light. Do not freeze.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Vous ne trouvez pas le bon produit ?  

Essayez notre Outil de sélection de produits.

Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

nwg

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable


Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

Sélectionner une référence de produit

Déjà en possession de ce produit ?

Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Les clients ont également consulté

Stephanie Puukila et al.
International journal of radiation biology, 95(8), 1072-1084 (2019-05-30)
Purpose: Diagnostic radiation is an important part of patient care in the Intensive Care Unit; however, there is little data on the acute effects of exposure to these doses. We investigated pulmonary and splenic response 30 minutes, 4 hours or 24 hours after
Marga J Bouma et al.
Stem cell research, 41, 101654-101654 (2019-11-18)
Lymphoblast cells from four individuals of a family of two genetically unrelated parents and their monozygotic twins were used to generate integration-free human induced pluripotent stem cells (hiPSCs). Reprogramming factors were delivered by co-electroporation of three episomal-based plasmids expressing OCT3/4
Katrin Kleinmanns et al.
EBioMedicine, 56, 102783-102783 (2020-05-27)
The completeness of resection is a key prognostic indicator in patients with ovarian cancer, and the application of tumour-targeted fluorescence image-guided surgery (FIGS) has led to improved detection of peritoneal metastases during cytoreductive surgery. CD24 is highly expressed in ovarian
Iveta Gažová et al.
Frontiers in cell and developmental biology, 8, 498-498 (2020-07-29)
The response of the human acute myeloid leukemia cell line THP-1 to phorbol esters has been widely studied to test candidate leukemia therapies and as a model of cell cycle arrest and monocyte-macrophage differentiation. Here we have employed Cap Analysis
Serena De Lucia et al.
PloS one, 13(1), e0191084-e0191084 (2018-01-18)
Artemisinin resistance is a major threat to malaria control efforts. Resistance is characterized by an increase in the Plasmodium falciparum parasite clearance half-life following treatment with artemisinin-based combination therapies (ACTs) and an increase in the percentage of surviving parasites. The

Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..

Contacter notre Service technique