BP576

Hydrocortisone

British Pharmacopoeia (BP) Assay Standard

• Synonyme(s) : 11β,17α,21-trihydroxypregn-4-ène-3,20-dione, 4-pregnène-11β,17α,21-triol-3,20-dione, Composé F de Kendall, Substance M de Reichstein
• Formule empirique (notation de Hill) : C₂₁H₃₀O₅
• CAS Number: 50-23-7
• Poids moléculaire : 362.46
• Beilstein: 1354819
• Numéro MDL: MFCD00011654
• Code UNSPSC : 41116107
• Nomenclature NACRES : NA.24

Propriétés

• Qualité: pharmaceutical primary standard
• Famille d'API: hydrocortisone
• Forme: solid
• Durée de conservation: limited shelf life, expiry date on the label
• Fabricant/nom de marque: BP
• Pf: 211-214 °C (lit.)
• Application(s): pharmaceutical; pharmaceutical small molecule
• Format: neat
• Chaîne SMILES: [H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]4(C)[C@@]2([H])CC[C@]4(O)C(=O)CO
• InChI: 1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1
• Clé InChI: JYGXADMDTFJGBT-VWUMJDOOSA-N
• Informations sur le gène: human ... NR3C1(2908)

Description

Description générale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Hydrocortisone BP Reference standard, intended for use in laboratory tests only as specifically prescribed in the British Pharmacopoeia.

Also used in monographs such as:

Tretinoin, Hydrocortisone and Hydroquinone Cream

Miconazole and Hydrocortisone Acetate Cream

Hydrocortisone Sodium Succinate Injection

Prednisolone Tablets

Miconazole and Hydrocortisone Cream

Miconazole and Hydrocortisone Ointment

Hydrocortisone and Neomycin Cream

Hydrocortisone and Clioquinol Ointment

Hydrocortisone Sodium Phosphate Oral Solution

Prednisolone Gastro-resistant Tablets

Hydrocortisone Sodium Phosphate

Hydrocortisone Sodium Phosphate Injection

Hydrocortisone and Clioquinol Cream

Methylprednisolone Tablets

Hydrocortisone Acetate Oral Suspension

Hydrocortisone Cream

Hydrocortisone Oromucosal Tablets

Actions biochimiques/physiologiques

Primary glucocorticoid secreted by the adrenal cortex. It has three times the anti-inflammatory potency of corticosterone but much lower Na²⁺ retention potency.

Principal glucocorticoïde secrété par la glande cortico-surrénale.

Autres remarques

Sales restrictions may apply.

Informations sur la sécurité

• Pictogrammes: GHS08
• Mention d'avertissement: Danger
• Mentions de danger: H360Df,H373
• Conseils de prudence: P202 - P260 - P280 - P308 + P313 - P405 - P501
• Classification des risques: Repr. 1A - STOT RE 2
• Organes cibles: Adrenal gland,Bone marrow
• Code de la classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable