D8809

Daunorubicin hydrochloride

meets USP testing specifications

• Synonyme(s) : Daunomycin hydrochloride
• Formule empirique (notation de Hill) : C₂₇H₂₉NO₁₀ · HCl
• CAS Number: 23541-50-6
• Poids moléculaire : 563.98
• Beilstein: 4229221
• Numéro CE : 245-723-4
• Numéro MDL: MFCD04974507
• Code UNSPSC : 41116107
• ID de substance PubChem : 24894229
• Nomenclature NACRES : NA.21

Propriétés

• Agence: USP/NF; meets USP testing specifications
• Niveau de qualité: 200
• Forme: solid
• Spectre d'activité de l'antibiotique: neoplastics
• Mode d’action: DNA synthesis | interferes
• Température de stockage: 2-8°C
• Chaîne SMILES: Cl.COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(C)=O
• InChI: 1S/C27H29NO10.ClH/c1-10-22(30)14(28)7-17(37-10)38-16-9-27(35,11(2)29)8-13-19(16)26(34)21-20(24(13)32)23(31)12-5-4-6-15(36-3)18(12)25(21)33;/h4-6,10,14,16-17,22,30,32,34-35H,7-9,28H2,1-3H3;1H/t10-,14-,16-,17-,22+,27-;/m0./s1
• Clé InChI: GUGHGUXZJWAIAS-QQYBVWGSSA-N
• Informations sur le gène: human ... TOP2A(7153)

Description

Actions biochimiques/physiologiques

Naturally fluorescent anthracycline antibiotic, anticancer drug. Substrate for Pgp, MRP-1 and BCRP. Fluorescent property has been exploited for the measurement of drug efflux pump activities as well as resolving the important question of intracellular localization of various multidrug resistance proteins and the role of subcellular organelles (golgi and lysosome) in the sequestration of drugs and its implication in drug resistant phenotypes. Daunorubicin is sequestered into lysosomes according to a pH partitioning type mechanism. Strong inhibitor of DNA and RNA synthesis.

Potent anticancer agent. Inhibits DNA and RNA synthesis as sequence specific ds-DNA intercalating agent.

Informations sur la sécurité

• Pictogrammes: GHS06,GHS08
• Mention d'avertissement: Danger
• Mentions de danger: H301,H341,H351,H360FD
• Conseils de prudence: P202 - P264 - P270 - P280 - P301 + P310 - P405
• Classification des risques: Acute Tox. 3 Oral - Carc. 2 - Muta. 2 - Repr. 1B
• Code de la classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 3
• Équipement de protection individuelle: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges