SMB00930

5-Methoxy-L-tryptophan

98-102%

• Synonyme(s) : 5-Methoxy-L-tryptophan, L-2-Amino-3-(5-methoxyindolyl)propionic acid
• Formule empirique (notation de Hill) : C₁₂H₁₄N₂O₃
• CAS Number: 25197-96-0
• Poids moléculaire : 234.25
• Code UNSPSC : 12352209
• Nomenclature NACRES : NA.26

Propriétés

• Niveau de qualité: 100
• Essai: 98-102%
• Forme: solid
• Activité optique: [α]20/D -30 to -28° in water
• Couleur: off-white to light yellow
• Température de stockage: 2-8°C
• Chaîne SMILES: [N+H3][C@@H](Cc1c2c([nH]c1)ccc(c2)OC)C(=O)[O-]
• InChI: 1S/C12H14N2O3/c1-17-8-2-3-11-9(5-8)7(6-14-11)4-10(13)12(15)16/h2-3,5-6,10,14H,4,13H2,1H3,(H,15,16)/t10-/m0/s1
• Clé InChI: KVNPSKDDJARYKK-JTQLQIEISA-N

Description

Description générale

5-Methoxy-L-tryptophan is a L-tryptophan metabolite that exhibits anti-inflammatory and tumor-suppressing activities. 5-Methoxy-L-tryptophan is synthesized by tryptophan hydroxylase (TPH) and hydroxyindole O-methyltransferase (HIOMT). A recent study indicates 5-methoxytryptophan as a biomarker of the progression of chronic kidney disease (CKD). Its levels decrease during disease and treatment with 5-methoxytryptophan ameliorates kidney fibrosis in mice model of CKD. 5-Methoxytryptophan appears to inhibit IκB/NFκB signaling and enhances Keap1/Nrf2 signaling in mice models of unilateral ureteral obstruction.

Application

5-Methoxy-L-tryptophan finds application in cell biology, biochemical and metabolomics research.

Caractéristiques et avantages

• Can be used in Metabolomics and Biochemical research
• High-quality compound suitable for multiple research applications

Autres remarques

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Informations sur la sécurité

• Pictogrammes: GHS06
• Mention d'avertissement: Danger
• Mentions de danger: H301
• Conseils de prudence: P264 - P270 - P301 + P310 - P405 - P501
• Classification des risques: Acute Tox. 3 Oral
• Code de la classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable