496219

N,N-Diisopropyléthylamine

99.5%, biotech. grade

• Synonyme(s) : N-Éthyldiisopropylamine, DIPEA, « Base de Hüning », Éthyldiisopropylamine
• Formule linéaire : [(CH₃)₂CH]₂NC₂H₅
• CAS Number: 7087-68-5
• Poids moléculaire : 129.24
• Numéro CE : 230-392-0
• Numéro MDL: MFCD00008868
• Code UNSPSC : 12352116
• ID de substance PubChem : 329757490
• Nomenclature NACRES : NA.21

Propriétés

• Qualité: biotech. grade
• Niveau de qualité: 200
• Pression de vapeur: 31 mmHg ( 37.7 °C)
• Essai: 99.5%
• Forme: liquid
• Impuretés: <0.050% water
• Couleur: APHA: <20
• Indice de réfraction: n20/D 1.414 (lit.)
• pH: 12.3 (20 °C)
• pb: 127 °C (lit.)
• Pf: <−50 °C (lit.)
• Solubilité: water: soluble 4.01 g/L at 20 °C
• Densité: 0.742 g/mL at 25 °C (lit.)
• Application(s): peptide synthesis
• Chaîne SMILES: CCN(C(C)C)C(C)C
• InChI: 1S/C8H19N/c1-6-9(7(2)3)8(4)5/h7-8H,6H2,1-5H3
• Clé InChI: JGFZNNIVVJXRND-UHFFFAOYSA-N

Description

Description générale

N, N-Diisopropylethylamine is a hindered non-nucleophilic amine base used in alkylation, aldol-like reactions, eliminations, and selective generation of enolates. It is widely used as a proton scavenger in organic synthesis. Due to its less nucleophilic nature, it produces less byproducts.

N, N-Diisopropylethylamine is a hindered non-nucleophilic amine base used in alkylation, aldol-like reactions, eliminations, and selective generation of enolates. It is widely used as a proton scavenger in organic synthesis. Due to its less nucleophilic nature, it produces less byproducts.

Application

N, N-Diisopropylethylamine can be used as a base:

• In the palladium (0)-catalyzed alkoxy carbonylation of allyl phosphates and acetate.
• In the selective enolate formation along with boryl triflates.
• In the C–N coupling of aryl halides with nitroarenes in the presence of nickel catalyst.

N,N-Diisopropylethylamine may be used in the synthesis of mannosylated ovalbumin peptides.

Informations sur la sécurité

• Pictogrammes: GHS02,GHS06,GHS05,GHS09
• Mention d'avertissement: Danger
• Mentions de danger: H225,H302,H318,H331,H335,H411
• Conseils de prudence: P210 - P273 - P280 - P301 + P312 - P304 + P340 + P311 - P305 + P351 + P338
• Classification des risques: Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Flam. Liq. 2 - STOT SE 3
• Organes cibles: Respiratory system
• Code de la classe de stockage: 3 - Flammable liquids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): 49.1 °F
• Point d'éclair (°C): 9.5 °C