27029

Cholate de sodium hydrate

≥97.0% (dried material, NT)

• Synonyme(s) : Acide 3α,7α,12α-trihydroxy-5β-cholan-24-oïque sodium salt, Acide cholalique sodium salt
• Formule empirique (notation de Hill) : C₂₄H₃₉NaO₅ · xH₂O
• CAS Number: 206986-87-0
• Poids moléculaire : 430.55 (anhydrous basis)
• Beilstein: 3582354
• Numéro CE : 206-643-5
• Numéro MDL: MFCD00150749
• Code UNSPSC : 12161900
• ID de substance PubChem : 57648188
• Nomenclature NACRES : NA.25

Propriétés

• Description: anionic
• Niveau de qualité: 200
• Essai: ≥97.0% (dried material, NT)
• Forme: powder
• Activité optique: [α]20/D +36±2°, c = 0.6% in ethanol (dry matter)
• Poids mol.: micellar avg mol wt 900-1300
• Nombre d'agrégation: 2-3
• Perte: ≤5% loss on drying
• CMC: 9-15 mM (20-25°C)
• Solubilité: H₂O: 0.1 M; H₂O: 100 mg/mL
• HLB: 18
• Chaîne SMILES: O.[Na+].C[C@H](CCC([O-])=O)C1CCC2C3[C@H](O)CC4C[C@H](O)CC[C@]4(C)C3C[C@H](O)[C@]12C
• InChI: 1S/C24H40O5.Na.H2O/c1-13(4-7-21(28)29)16-5-6-17-22-18(12-20(27)24(16,17)3)23(2)9-8-15(25)10-14(23)11-19(22)26;;/h13-20,22,25-27H,4-12H2,1-3H3,(H,28,29);;1H2/q;+1;/p-1/t13-,14+,15-,16-,17+,18+,19-,20+,22+,23+,24-;;/m1../s1
• Clé InChI: MUVVIYFKOVLQHL-RCVKHMDESA-M

Description

Description générale

Sodium cholate hydrate is a bio-surfactant which can be used as a reducing reagent in aqueous solution.

Sodium cholate hydrate is a non-denaturing, anionic detergent.

Application

• Optimization in Transdermal Drug Delivery: Applied in the formulation of ultra-elastic nanovesicles, sodium cholate hydrate enhances the bioavailability and anti-inflammatory efficacy of deflazacort, demonstrating its potential in transdermal drug delivery systems, which can be adapted for diagnostic purposes (Ali et al., 2021).


• Nanocarrier Formulations for IVDs: The study utilizes sodium cholate hydrate in the surface modification of bilosomes, serving as a functional and biocompatible nanocarrier for hybrid compounds, a method applicable to the formulation of innovative IVD reagents (Waglewska et al., 2020).


• IVD Reagent Formulation for Skin Delivery: Sodium cholate hydrate is featured in the development of nano-transfersomes for the delivery of antioxidants, showcasing its role in creating skin-applied diagnostic reagents that offer antioxidant and anti-aging effects (Avadhani et al., 2017).


• Sorting and Separation Techniques in Nanotechnology: Demonstrating the affinity-mediated sorting order reversal, sodium cholate hydrate is critical in density gradient ultracentrifugation techniques, highlighting its utility in the precise sorting and preparation of materials for diagnostic assays (Jang et al., 2016).

Informations sur la sécurité

• Mentions de danger: H412
• Conseils de prudence: P273 - P501
• Classification des risques: Aquatic Chronic 3
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)