39220

Dansyl chloride

suitable for fluorescence, BioReagent, ≥99.0% (HPLC)

• Synonyme(s) : 1-Dimethylaminonaphthalene-5-sulfonyl chloride, 5-(Dimethylamino) naphthalene-1-sulfonyl chloride, DNS Chloride, DNSCl, 5-(Dimethylamino)naphthalene-1-sulfonyl chloride
• Formule empirique (notation de Hill) : C₁₂H₁₂ClNO₂S
• CAS Number: 605-65-2
• Poids moléculaire : 269.75
• Beilstein: 2217205
• Numéro CE : 210-092-6
• Numéro MDL: MFCD00003985
• Code UNSPSC : 12352101
• ID de substance PubChem : 329755828
• Nomenclature NACRES : NA.32

Propriétés

• Gamme de produits: BioReagent
• Niveau de qualité: 200
• Essai: ≥99.0% (HPLC)
• Pf: 72-74 °C (lit.)
• Solubilité: acetone: 0.2 g/10 mL
• Fluorescence: λ_ex 337 nm; λ_em 492 nm in chloroform (after derivatization with hexylamine)
• Adéquation: suitable for fluorescence
• Température de stockage: 2-8°C
• Chaîne SMILES: CN(C)c1cccc2c(cccc12)S(Cl)(=O)=O
• InChI: 1S/C12H12ClNO2S/c1-14(2)11-7-3-6-10-9(11)5-4-8-12(10)17(13,15)16/h3-8H,1-2H3
• Clé InChI: XPDXVDYUQZHFPV-UHFFFAOYSA-N

Description

Description générale

Dansyl Chloride, also known as 5-dimethylamino naphthalene-1-sulfonyl chloride, is a pre-column derivatization reagent. After the derivatization reaction, the fluorescent derivatives are analyzed using several analytical methods like NMR, IR, UV-vis, and fluorescence microscopy. Dansyl Chloride is a typical aromatic sulphonyl chloride that reacts with various bases, resulting in derivatives with variable stability.

Application

A fluorogenic reagent for fluorescent N-terminal derivatization of amino acids and peptides and detection by reverse phase HPLC.

Dansyl Chloride is used as a derivatization reagent to study extensive metabolism and low doses of ethinylestradiol administered during pre-clinical studies. Studies conducted to determine bisphenols in human serum through the HPLC method used Dansyl Chloride to obtain the derivative products. Dansyl Chloride derivatives are suitable for LC/MS determination and characterization of glyphosate, aminomethylphosphonic acid (AMPA), and glufosinate from food samples.

Informations sur la sécurité

• Pictogrammes: GHS05
• Mention d'avertissement: Danger
• Mentions de danger: H290,H314
• Conseils de prudence: P260 - P280 - P303 + P361 + P353 - P305 + P351 + P338 + P310
• Classification des risques: Eye Dam. 1 - Met. Corr. 1 - Skin Corr. 1B
• Code de la classe de stockage: 8A - Combustible corrosive hazardous materials
• Classe de danger pour l'eau (WGK): WGK 3
• Équipement de protection individuelle: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges