475R-9

INSM1 (MRQ-70) Rabbit Monoclonal Antibody

• Synonyme(s) : Insulinoma-associated protein 1
• Code UNSPSC : 12352203

Propriétés

• Source biologique: rabbit
• Niveau de qualité: 100; 500
• Conjugué: unconjugated
• Forme d'anticorps: culture supernatant
• Type de produit anticorps: primary antibodies
• Clone: MRQ-70, monoclonal
• Description: For In Vitro Diagnostic Use in Select Regions
• Forme: buffered aqueous solution
• Espèces réactives: human
• Conditionnement: vial of 0.1 mL concentrate (475R-94); vial of 0.1 mL concentrate Research Use Only (475R-94-RUO); vial of 0.5 mL concentrate (475R-95); vial of 1.0 mL concentrate (475R-96); vial of 1.0 mL concentrate Research Use Only (475R-96-RUO); vial of 1.0 mL pre-dilute Research Use Only (475R-97-RUO); vial of 1.0 mL pre-dilute ready-to-use (475R-97); vial of 7.0 mL pre-dilute ready-to-use (475R-98); vial of 7.0 mL pre-dilute ready-to-use Research Use Only (475R-98-RUO)
• Fabricant/nom de marque: Cell Marque^®
• Technique(s): immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100 (concentrated)
• Isotype: IgG
• Contrôle: pancreas
• Conditions d'expédition: wet ice
• Température de stockage: 2-8°C
• Visualisation: nuclear

Description

Description générale

Insulinoma-associated protein 1 (INSM1) is a transcriptional factor with a zinc finger DNA-binding domain that is involved in neuroendocrine cell differentiation as a transcriptional repressor¹. INSM1 expression has been observed during embryonic development in the cerebellum, spinal cord, olfactory epithelium, pancreas, and gastrointestinal tract^2-4; however, expression in healthy adult tissues is limited to neuroendocrine cells. INSM1 is over expressed in neuroendocrine neoplasms including carcinoids, small cell carcinomas, and neuroendocrine carcinomas. This helps in identification of neuroendocrine tumors and their distinction from other lesions, such as adenocarcinomas, which exhibit little to no INSM1 expression^5-6.

Qualité

United States - IVD
Canada - RUO
European Union - IVD
Japan - RUO

Forme physique

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Notes préparatoires

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Autres remarques

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Informations légales

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 12 - Non Combustible Liquids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable