53747

Hyaluronic acid sodium salt from Streptococcus equi

bacterial glycosaminoglycan polysaccharide

• Synonyme(s) : Poly(β-glucuronic acid-[1→3]-β-N-acetylglucosamine-[1→4]), alternating
• CAS Number: 9067-32-7
• Numéro MDL: MFCD00875848
• Code UNSPSC : 51202002
• ID de substance PubChem : 24878223
• Nomenclature NACRES : NA.25

Propriétés

• Source biologique: (Streptococcus equi)
• Niveau de qualité: 200
• Forme: powder or crystals
• Poids mol.: ~1.5-1.8 x 10E6 Da
• Impuretés: ≤1% protein
• Couleur: white
• Solubilité: H₂O: 5 mg/mL, clear, colorless
• Température de stockage: −20°C
• Chaîne SMILES: [Na+].CC(=O)N[C@@H]1C[C@H](O)[C@@H](CO)O[C@H]1O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2C([O-])=O
• InChI: 1S/C28H44N2O23.Na/c1-5(33)29-9-18(11(35)7(3-31)47-25(9)46)49-28-17(41)15(39)20(22(53-28)24(44)45)51-26-10(30-6(2)34)19(12(36)8(4-32)48-26)50-27-16(40)13(37)14(38)21(52-27)23(42)43;/h7-22,25-28,31-32,35-41,46H,3-4H2,1-2H3,(H,29,33)(H,30,34)(H,42,43)(H,44,45);/q;+1/t7-,8-,9-,10-,11-,12-,13+,14+,15-,16-,17-,18-,19-,20+,21+,22+,25-,26+,27-,28-;/m1./s1
• Clé InChI: YWIVKILSMZOHHF-QJZPQSOGSA-N

Description

Description générale

Hyaluronic acid (HA), a vital component of the extracellular matrix in the central nervous system, is the versatile macromolecule found in the connective tissues of all vertebrates. This supramolecular glycosaminoglycan is a polyanionic natural polymer occurring as a linear polysaccharide. It is made up of glucuronic acid and N-acetylglucosamine repeats through a β-1,4 linkage. HA is seen abundantly in the eyes, joints, and heart valves.

Application

Hyaluronic acid sodium salt from Streptococcus equi has been used:

• with methacrylic anhydride for synthesizing cross-linkable methacrylated HA hydrogel (Coll-MeHA)
• in phosphate buffer saline (PBS) to replace the PBS bath to vary the lubricant composition
• in the preparation of lubricant to study its effects on the boundary lubrication of human osteoarthritis (OA) cartilage

Actions biochimiques/physiologiques

Hyaluronic acid (HA), an important component of synovial fluid and articular cartilage serves as the boundary lubricant. It exhibits several physicochemical properties including biodegradability, biocompatibility, nontoxicity, and nonimmunogenicity. HA is considered a great tool for biomedical uses like drug delivery, tissue engineering, plastic surgery, ocular surgery, and osteoarthritis surgery. It participates in cushioning and lubricating the body. This powerful antioxidant can bond water to tissue.

Autres remarques

To gain a comprehensive understanding of our extensive range of Polysaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable