62962

L-α-Lysophosphatidylcholine

egg yolk, ≥99.0% (TLC)

• Synonyme(s) : 3-sn-Lysophosphatidylcholine, L-α-Lysolecithin
• Numéro MDL: MFCD00131444
• Code UNSPSC : 51321705
• Nomenclature NACRES : NA.25

Propriétés

• Source biologique: egg yolk
• Description: zwitterionic
• Essai: ≥99.0% (TLC)
• Forme: powder or solid
• Composition: 16:0, ~69% (fatty acid); 18:0, ~27% (fatty acid); 18:1, ~3% (fatty acid)
• Solubilité: chloroform/methanol: 50 mg/mL, clear, colorless to very faintly yellow
• Groupe fonctionnel: phospholipid
• Type de lipide: phosphoglycerides
• Conditions d'expédition: wet ice
• Température de stockage: −20°C

Description

Application

• The activation mode of the mechanosensitive ion channel, MscL, by lysophosphatidylcholine differs from tension-induced gating: L-α-LPC is explored for its unique interaction with ion channels, suggesting its potential as a tool for studying channel mechanics and developing new therapeutic strategies for diseases linked to cellular mechanics (Mukherjee et al., 2014).


• Aerosol delivery of an enhanced helper-dependent adenovirus formulation to rabbit lung using an intratracheal catheter: The use of L-α-LPC in enhancing the delivery of gene therapy vectors via aerosol demonstrates its utility in improving the efficiency of gene therapies, particularly for respiratory diseases (Koehler et al., 2005).

Actions biochimiques/physiologiques

3-sn-Lysophosphatidylcholine, besides contributing to the positive curvature of membranes , inhibits SNARE complex disassembly in vitro and in rat nerve terminals and exocrine pancrease .

Autres remarques

Preparation of demembranated frog sperm chromatin

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)