87128

Tetracycline

98.0-102.0% (HPLC)

• Synonyme(s) : Tetracycline HCL, Tetracycline Monohydrochloride
• Formule empirique (notation de Hill) : C₂₂H₂₄N₂O₈ · xH₂O
• CAS Number: 60-54-8
• Poids moléculaire : 444.43 (anhydrous basis)
• Beilstein: 2230417
• Numéro CE : 200-481-9
• Numéro MDL: MFCD00151232
• Code UNSPSC : 51284017
• ID de substance PubChem : 57653229
• Nomenclature NACRES : NA.85

Propriétés

• Source biologique: synthetic
• Niveau de qualité: 200
• Essai: 98.0-102.0% (HPLC)
• Forme: powder or crystals
• Couleur: faint yellow to dark yellow
• Pf: 172-174 °C (dec.)
• Spectre d'activité de l'antibiotique: Gram-negative bacteria; Gram-positive bacteria
• Mode d’action: protein synthesis | interferes
• Température de stockage: 2-8°C
• Chaîne SMILES: CN(C)[C@H]1[C@@H]2C[C@H]3C(=C(O)[C@]2(O)C(=O)C(C(N)=O)=C1O)C(=O)c4c(O)cccc4[C@@]3(C)O
• InChI: 1S/C22H24N2O8/c1-21(31)8-5-4-6-11(25)12(8)16(26)13-9(21)7-10-15(24(2)3)17(27)14(20(23)30)19(29)22(10,32)18(13)28/h4-6,9-10,15,25,27-28,31-32H,7H2,1-3H3,(H2,23,30)/t9-,10-,15-,21+,22-/m0/s1
• Clé InChI: OFVLGDICTFRJMM-WESIUVDSSA-N
• Informations sur le gène: human ... CYP1A2(1544), TERT(7015)

Description

Description générale

Chemical structure: tetracycline

Actions biochimiques/physiologiques

Mode of Action: Tetracycline passively diffuses through proin channels in the cell membrane, binding to 30S ribosomes and inhibits protein synthesis by preventing access of aminoacyl tRNA to the acceptor site on the mRNA-ribosome complex. It also binds to the bacterial 50S ribosomal subunit, altering the membrane and causing intracellular components to leak from bacterial cells. The inhibitory effects can be reversed by washing, suggesting that it is the reversibly bound antibiotic, and not the irreversibly bound drug, that is responsible for antibacterial action.

Mode of Resistance: The effects are inactivated via a loss of cell wall permeability.

Antimicrobial spectrum: Includes a wide range of antimicrobial activity against gram-positive and gram-negative bacteria.

Conditionnement

25g, 100g

Autres remarques

Keep container tightly closed in a dry and well-ventilated place.Hygroscopic. Light sensitive. Keep in a dry place.

Informations sur la sécurité

• Pictogrammes: GHS08,GHS07,GHS09
• Mention d'avertissement: Warning
• Mentions de danger: H302,H361fd,H411
• Conseils de prudence: P202 - P264 - P273 - P280 - P301 + P312 - P308 + P313
• Classification des risques: Acute Tox. 4 Oral - Aquatic Chronic 2 - Repr. 2
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves