90790

L-α-Hydroxyglutaric acid disodium salt

≥98.0% (GC)

• Synonyme(s) : (S)-2-Hydroxypentanedioic acid disodium salt, Disodium (S)-2-hydroxyglutarate
• Formule linéaire : C₅H₆O₅Na₂
• CAS Number: 63512-50-5
• Poids moléculaire : 192.08
• Beilstein: 5318042
• Numéro MDL: MFCD00021700
• Code UNSPSC : 12352106
• ID de substance PubChem : 329769949
• Nomenclature NACRES : NA.32

Propriétés

• Niveau de qualité: 100
• Essai: ≥98.0% (GC)
• Forme: powder or crystals
• Activité optique: [α]/D -8.5±1.5°, c = 1 in 0.1 M NaOH
• Impuretés: ≤6.0% water
• Maladie(s) pertinente(s): cancer
• Température de stockage: 2-8°C
• Chaîne SMILES: [O-]C(CC[C@@H](C([O-])=O)O)=O.[Na+].[Na+]
• InChI: 1S/C5H8O5.2Na/c6-3(5(9)10)1-2-4(7)8;;/h3,6H,1-2H2,(H,7,8)(H,9,10);;/q;2*+1/p-2/t3-;;/m0../s1
• Clé InChI: DZHFTEDSQFPDPP-QTNFYWBSSA-L

Description

Description générale

Glutamic acid is metabolized to α-Hydroxyglutaric acid in an NAD-dependent manner by cell-free extracts of Peptococcus aerogenes. It is formed as an intermediate during glyoxylic acid metabolism in bacteria.

Application

L-α-Hydroxyglutaric acid disodium salt is suitable for use in collection buffer for increased recovery of hypoxia-inducible factor-1 α (HIF-1α), a marker of hypoxia in human tumors. It is also suitable for the radiolabeled 5mC-5hmC conversion assay to study the effect of 2-HG on the TET family of methyl hydroxylases.

Actions biochimiques/physiologiques

L-alpha-Hydroxyglutaric acid accumulates as a result of a rare defect in L-2-HG dehydogenase, leading to the metabolic disorder L-2-hydroxyglutaric aciduria (L-2HGA). L-2HGA is associated with neuronal defects, leukodystrophy and linked to an increased risk of brain tumors.

Conditionnement

Bottomless glass bottle. Contents are inside inserted fused cone.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable