A0326

(S)-AMPA

≥97%

• Synonyme(s) : (S)-α-Amino-3-hydroxy-5-methylisoxazole-4-propionic acid
• Formule empirique (notation de Hill) : C₇H₁₀N₂O₄
• CAS Number: 83643-88-3
• Poids moléculaire : 186.17
• Numéro MDL: MFCD00672630
• Code UNSPSC : 12352200
• ID de substance PubChem : 24890421
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥97%
• Forme: powder
• Chaîne SMILES: Cc1onc(O)c1C[C@H](N)C(O)=O
• InChI: 1S/C7H10N2O4/c1-3-4(6(10)9-13-3)2-5(8)7(11)12/h5H,2,8H2,1H3,(H,9,10)(H,11,12)/t5-/m0/s1
• Clé InChI: UUDAMDVQRQNNHZ-YFKPBYRVSA-N
• Informations sur le gène: human ... GRIA1(2890), GRIA2(2891), GRIA4(2893), GRIK1(2897) ; mouse ... Gria1(14799) ; rat ... Gria1(50592), Gria2(29627), Gria3(29628), Gria4(29629), Grik1(29559), Grik2(54257), Grik4(24406), Grin2a(24409), Grin2b(24410), Grm6(24419)

Description

Description générale

AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) activates excitatory postsynaptic currents (EPSC).

Application

(S)-AMPA has also been used to activate rostromedial tegmental nucleus (RMTg), to study aversive conditioning in relation with cocaine-induced avoidance behaviors in mice.

(S)-AMPA has been used to selectively eliminate the neural cochlear component of adult barn owls by destroying afferent synapses.

Actions biochimiques/physiologiques

Active enantiomer of (RS)-AMPA zwitterion. Potent agonist at the AMPA subclass of ionotropic glutamate receptors.

Potent agonist at the AMPA subclass of ionotropic glutamate receptors; active enantiomer.

Caractéristiques et avantages

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This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)