A0980

AM281

≥98% (HPLC)

• Synonyme(s) : 1-(2,4-Dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-4-morpholinyl-1H-pyrazole-3-carboxamide, AM 281
• Formule empirique (notation de Hill) : C₂₁H₁₉Cl₂IN₄O₂
• CAS Number: 202463-68-1
• Poids moléculaire : 557.21
• Numéro MDL: MFCD01861180
• Code UNSPSC : 12352200
• ID de substance PubChem : 24724384
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: powder
• Conditions de stockage: desiccated
• Couleur: white
• Solubilité: DMSO: >6 mg/mL; H₂O: insoluble
• Température de stockage: 2-8°C
• Chaîne SMILES: Cc1c(nn(-c2ccc(Cl)cc2Cl)c1-c3ccc(I)cc3)C(=O)NN4CCOCC4
• InChI: 1S/C21H19Cl2IN4O2/c1-13-19(21(29)26-27-8-10-30-11-9-27)25-28(18-7-4-15(22)12-17(18)23)20(13)14-2-5-16(24)6-3-14/h2-7,12H,8-11H2,1H3,(H,26,29)
• Clé InChI: AJFFBPZYXRNAIC-UHFFFAOYSA-N
• Informations sur le gène: rat ... Cnr1(25248)

Description

Application

AM281 has been used as a cannabinoid 1 receptor antagonist:

• to study its effects on memory deficit following naloxone-precipitated morphine withdrawal in mice
• to study the role of CB1 receptor system in modulating acetaldehyde-induced effects in rats during the extinction-, relapse-, and conflict-experiments
• to study its effect on scopolamine-induced memory deficit using object recognition paradigm
• to block synthetic cannabinoid (HU210)-induced analgesia in the ventrolateral orbital cortex (VLO) to evaluate the effect of CB1 receptors on the VLO modulation of pain

Actions biochimiques/physiologiques

AM281 is less lipophilic compared to its analog SR 141716A, a cannabinoid receptor antagonist. AM281 may prevent memory deficit post morphine withdrawal by inhibiting cannabinoid receptors in mice.

Potent and selective CB₁ cannabinoid receptor antagonist/inverse agonist

Caractéristiques et avantages

This compound is featured on the Cannabinoid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informations sur la sécurité

• Pictogrammes: GHS06
• Mention d'avertissement: Danger
• Mentions de danger: H300,H315,H319,H335
• Conseils de prudence: P261 - P264 - P271 - P301 + P310 - P302 + P352 - P305 + P351 + P338
• Classification des risques: Acute Tox. 2 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Organes cibles: Respiratory system
• Code de la classe de stockage: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges