A129

Amoxapine

• Synonyme(s) : 2-Chloro-11-(1-piperazinyl)dibenz[b,f][1,4]oxazepine
• Formule empirique (notation de Hill) : C₁₇H₁₆ClN₃O
• CAS Number: 14028-44-5
• Poids moléculaire : 313.78
• Numéro CE : 237-867-1
• Numéro MDL: MFCD00069210
• Code UNSPSC : 12352200
• ID de substance PubChem : 24278075
• Nomenclature NACRES : NA.77

Propriétés

• Forme: powder
• Niveau de qualité: 100
• Solubilité: methanol: soluble
• Auteur: Wyeth
• Chaîne SMILES: Clc1ccc2Oc3ccccc3N=C(N4CCNCC4)c2c1
• InChI: 1S/C17H16ClN3O/c18-12-5-6-15-13(11-12)17(21-9-7-19-8-10-21)20-14-3-1-2-4-16(14)22-15/h1-6,11,19H,7-10H2
• Clé InChI: QWGDMFLQWFTERH-UHFFFAOYSA-N
• Informations sur le gène: human ... DRD1(1812), DRD2(1813), DRD3(1814), DRD4(1815), DRD5(1816), HTR2A(3356), HTR2B(3357), HTR2C(3358), SLC6A2(6530), SLC6A4(6532)

Description

Application

Amoxapine has been used as an antidepressant drug to test its effect on locomotion and egg release in response to gain-of-functional mutations in potassium (K⁺) channels (unc-58) of C. elegans. It has also been used as an antipsychotic drug to test its effect on the viability of glioblastoma cells.

Actions biochimiques/physiologiques

Amoxapine, a structural analog of clozapine, is a human ether a-go-go (hERG) channel blocker. It is also an N-methylated metabolite of loxapine. It is a tricyclic antidepressant that inhibits the uptake of norepinephrine and blocks 5- hydroxytryptamine (HT2 ) serotonergic receptors.

Caractéristiques et avantages

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Wyeth. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H302
• Conseils de prudence: P264 - P270 - P301 + P312 - P501
• Classification des risques: Acute Tox. 4 Oral
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Faceshields, Gloves