A1439

Pituitary adenylate cyclase activating polypeptide-38

• Synonyme(s) : PACAP-38
• Formule empirique (notation de Hill) : C₂₀₃H₃₃₁N₆₃O₅₃S
• CAS Number: 137061-48-4
• Poids moléculaire : 4534.26
• Numéro MDL: MFCD00081800
• Code UNSPSC : 41106305
• Nomenclature NACRES : NA.32

Propriétés

• Forme: powder
• Niveau de qualité: 200
• Composition: Peptide content, ~70%
• Numéro d'accès UniProt: P18509
• Température de stockage: −20°C
• Informations sur le gène: human ... ADCYAP1(116)

Description

Amino Acid Sequence

His-Ser-Asp-Gly-Ile-Phe-Thr-Asp-Ser-Tyr-Ser-Arg-Tyr-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Ala-Ala-Val-Leu-Gly-Lys-Arg-Tyr-Lys-Gln-Arg-Val-Lys-Asn-Lys-NH2

Description générale

Pituitary adenylate cyclase activating polypeptide-38 (PACAP38) is mapped to human chromosome 18. 27-residue-amidated fragment (PACAP27) comprises another isoform. The PACAP38 is major isoform associated with mammals.

Application

Pituitary adenylate cyclase activating polypeptide-38 has been used to test its effect in stimulating the formation of cyclic AMP hypothalamus and cerebral cortex slices of chicken and to treat glioblastoma cells (U87MG) in cell migration assay to test its anti-invasive effects.

Actions biochimiques/physiologiques

PACAP-38 is a neuropeptide that has substantial sequence homology to vasoactive intestinal peptide (VIP). It is reported to serve as a neuronal survival factor.

Pituitary adenylate cyclase activating polypeptide-38 (PACAP38) is a cardioprotectant and may help in treating radiation-induced heart disease (RIHD). It plays a protective role during oxidative stress in cardiomyocytes. PACAP38 has antioxidant, anti-apoptotic and anti-inflammatory property. It is implicated in the pathophysiology of migraine and cluster headache.

Autres remarques

Lyophilized from 0.1% TFA in H2O

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)