A1824

N-Acetyl-5-hydroxytryptamine

≥99% (HPLC), powder, antioxidant

• Synonyme(s) : N-Acetylserotonin, Normelatonin
• Formule empirique (notation de Hill) : C₁₂H₁₄N₂O₂
• CAS Number: 1210-83-9
• Poids moléculaire : 218.25
• Numéro CE : 214-916-5
• Numéro MDL: MFCD00005656
• Code UNSPSC : 12352209
• ID de substance PubChem : 24278209
• Nomenclature NACRES : NA.32

Propriétés

• Product Name: N-Acetyl-5-hydroxytryptamine, ≥99% (HPLC), powder
• Niveau de qualité: 200
• Essai: ≥99% (HPLC)
• Forme: powder
• Couleur: white to faint yellow
• Pf: 120-122 °C (lit.)
• Solubilité: ethanol: 50 mg/mL
• Température de stockage: 2-8°C
• Chaîne SMILES: CC(=O)NCCc1c[nH]c2ccc(O)cc12
• InChI: 1S/C12H14N2O2/c1-8(15)13-5-4-9-7-14-12-3-2-10(16)6-11(9)12/h2-3,6-7,14,16H,4-5H2,1H3,(H,13,15)
• Clé InChI: MVAWJSIDNICKHF-UHFFFAOYSA-N
• Informations sur le gène: human ... MTNR1A(4543), MTNR1B(4544)

Description

Description générale

N-Acetylserotonin (NAS)/normelatonin acts as a precursor of melatonin in the tryptophan metabolic pathway.

Application

N-Acetyl-5-hydroxytryptamine has been used to treat neuron cells and to analyze its effects on Krüppel-like factor 15 (KLF15) expression.

Actions biochimiques/physiologiques

N-acetyl-serotonin (NAS/normelatonin) can act as a shelter to neurons due to its protecting ability against oxidative challenges. It can also repress the actions of the transcription factor NF-kappaB. NAS possesses antioxidant and antiaging actions. It has protective action against β-amyloid induced neurotoxicity. It helps to maintain the optimal fluidity of the biological membranes.

Immediate precursor of melatonin. It is formed from serotonin and acetyl-CoA in a reaction catalyzed by serotonin N-acetyl transferase, the rate-limiting enzyme in melatonin biosynthesis. This indoleamine is a weak agonist at melatonin receptors, and has moderate effects on G-protein stimulation and inhibition of cAMP accumulation.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)