A1960

Aggrecan from bovine articular cartilage

lyophilized powder

• Synonyme(s) : Aggrecan Protein
• Numéro MDL: MFCD00676441
• Code UNSPSC : 12352202
• Nomenclature NACRES : NA.75

Propriétés

• Source biologique: bovine articular cartilage
• Niveau de qualité: 200
• Forme: lyophilized powder
• Conditionnement: glass bottle of 1 mg
• Technique(s): cell culture | mammalian: suitable
• Impuretés: salt, essentially free
• Couleur: white
• Solubilité: H₂O: 2 mg/mL
• Numéro d'accès UniProt: P13608
• Conditions d'expédition: wet ice
• Température de stockage: −20°C
• Informations sur le gène: cow ... AGC1(280985)

Description

Application

Aggrecan is a critical component for cartilage structure and the function of joints. Its synthesis and degradation are being studied for their roles in cartilage deterioration during joint injury disease and aging.

Actions biochimiques/physiologiques

This molecule produces a rigid, reversibly deformable gel that resists compression. It combines with hyaluronic acid to form very large macromolecular complexes that have an increased hydrohynamic volume and a significant increase (30-40%) in the relative viscosity of the solution.

Composants

Aggrecan is a major structural proteoglycan of the cartilage extracellular matrix. It is a large proteoglycan, with a molecular weight greater than 2,500 kDa composed of approximately 100-150 glycosaminoglycan chains attached to a core protein. The majority of these glycosaminoglycan chains are chondroitin/dermatan sulfate. Aggrecan contains three globular domains, G1, G2, and G3, which are involved in aggregation and hylauronan binding, cell adhesion and chondrycte apoptosis.

Attention

Store this product at -20°C. Stored as supplied, this powder shows little decomposition in 3 years when stored properly.

Notes préparatoires

This product is extracted from articular cartilage, chematographically purified, dialyzed against water, and 0.2 μm filtered prior to lyophilization. Once lyophilized, this powder is essentially salt-free. The product is soluble in water at 2 mg/mL.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)