A2201

Amyloid β-Protein Fragment 35-25

≥95% (HPLC)

• Formule empirique (notation de Hill) : C₄₅H₈₁N₁₃O₁₄S
• CAS Number: 147740-73-6
• Poids moléculaire : 1060.27
• Numéro MDL: MFCD00214225
• Code UNSPSC : 51111800
• ID de substance PubChem : 24890634
• Nomenclature NACRES : NA.32

Propriétés

• Niveau de qualité: 200
• Essai: ≥95% (HPLC)
• Forme: powder
• Numéro d'accès UniProt: P05067
• Température de stockage: −20°C
• Chaîne SMILES: CCC(C)C(NC(=O)CNC(=O)C(CC(C)C)NC(=O)C(N)CCSC)C(=O)NC(C(C)CC)C(=O)NC(C)C(=O)NCC(=O)NC(CCCCN)C(=O)NC(CC(N)=O)C(=O)NC(CO)C(=O)NCC(O)=O
• InChI: 1S/C45H81N13O14S/c1-9-24(5)36(57-34(62)20-50-40(67)29(17-23(3)4)54-39(66)27(47)14-16-73-8)45(72)58-37(25(6)10-2)44(71)52-26(7)38(65)49-19-33(61)53-28(13-11-12-15-46)42(69)55-30(18-32(48)60)43(70)56-31(22-59)41(68)51-21-35(63)64/h23-31,36-37,59H,9-22,46-47H2,1-8H3,(H2,48,60)(H,49,65)(H,50,67)(H,51,68)(H,52,71)(H,53,61)(H,54,66)(H,55,69)(H,56,70)(H,57,62)(H,58,72)(H,63,64)
• Clé InChI: IDGOADDOQWKZOX-UHFFFAOYSA-N
• Informations sur le gène: human ... APP(351)

Description

Amino Acid Sequence

Met-Leu-Gly-Ile-Ile-Ala-Gly-Lys-Asn-Ser-Gly

Description générale

Amyloid β precursor protein (APP) is a type-1 transmembrane protein. APP is expressed widely and mainly found in the synapses and neurons. The APP gene is mapped to human chromosome 21q21.3.

Application

Amyloid β-Protein Fragment 35-25 has been used as a control peptide for Aβ-induced apoptosis to study the role of hepcidin overexpression in astrocytes against amyloid-β induced brain damage in mice.

Actions biochimiques/physiologiques

Proteolytic processing of amyloid β precursor protein (APP) forms the β amyloid protein (Aβ) as part of the brain amyloid plaques which are the key biomarkers in Alzheimer′s disease. APP is known to be associated with neurogenesis, synapse formation, axonal transport, neuronal migration and neurite outgrowth. It is also related to mitochondria-associated endoplasmic reticulum membranes (MAMs) activity, antimicrobial protection, cholesterol, and iron homeostasis. Amyloid β-Protein Fragment 35-25 is an inactive control.

Autres remarques

The N—C inverted sequence of fragment 25-35

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)