A2647

Adenosine 5′-(β,γ-imido)triphosphate lithium salt hydrate

≥93% (HPLC), powder

• Synonyme(s) : β,γ-Imidoadenosine 5′-triphosphate lithium salt hydrate, AMP-PNP, ATP[β,γ-NH], Adenylyl imidodiphosphate lithium salt hydrate, App(NH)p
• Formule empirique (notation de Hill) : C₁₀H₁₇N₆O₁₂P₃ · xLi⁺ · yH₂O
• CAS Number: 25612-73-1
• Poids moléculaire : 506.20 (free acid basis)
• Beilstein: 6047109
• Numéro MDL: MFCD03424105
• Code UNSPSC : 41106305
• ID de substance PubChem : 24890685
• Nomenclature NACRES : NA.51

Propriétés

• Source biologique: natural (organic)
• Niveau de qualité: 200
• Essai: ≥93% (HPLC)
• Forme: powder
• Couleur: white
• Solubilité: H₂O: 50 mg/mL
• Conditions d'expédition: dry ice
• Température de stockage: −20°C
• Chaîne SMILES: [Li+].[Li+].[Li+].[Li+].[H]O[H].Nc1ncnc2n(cnc12)[C@@H]3O[C@H](COP([O-])(=O)OP([O-])(=O)NP([O-])([O-])=O)[C@@H](O)[C@H]3O
• InChI: 1S/C10H17N6O12P3/c11-8-5-9(13-2-12-8)16(3-14-5)10-7(18)6(17)4(27-10)1-26-31(24,25)28-30(22,23)15-29(19,20)21/h2-4,6-7,10,17-18H,1H2,(H,24,25)(H2,11,12,13)(H4,15,19,20,21,22,23)/t4-,6-,7-,10-/m1/s1
• Clé InChI: PVKSNHVPLWYQGJ-KQYNXXCUSA-N

Description

Application

Adenosine 5′-(β,γ-imido)triphosphate lithium salt hydrate has been used in a study to research the effects of monovalent cations Li⁺, Na⁺, K⁺, NH₄⁺, Rb⁺ and Cs⁺ on the solid and solution structures of the nucleic acid components. Adenosine 5′-(β,γ-imido)triphosphate lithium salt hydrate has also been used in a study to determine that antidepressants inhibit interferon-γ-induced microglial production of IL-6 and nitric oxide.

Actions biochimiques/physiologiques

A non-hydrolyzable ATP analog. AMP-PNP competitively inhibits ATP-dependent enzyme systems, such as glutamine synthetase. It inhibits a number of enzymes which require the hydrolysis of ATP such as DNA topoisomerase II, SV40 large T-antigen helicase and a number of kinases. Blocks ATP-sensitive calcium-dependent potassium channels.

Attention

AMP-PNP is very unstable in acidic conditions; rapidly hydrolyzes to the phosphoramidate and inorganic phosphate.

Reconstitution

A 10 mg/mL stock solution may be made, aliquoted and stored at -70 °C for up to 3 months.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)