A7154

Adenosine, periodate oxidized

≥93%

• Synonyme(s) : ADOX, Adenosine-2′,3′-dialdehyde
• Formule empirique (notation de Hill) : C₁₀H₁₁N₅O₄
• CAS Number: 34240-05-6
• Poids moléculaire : 265.23
• Numéro MDL: MFCD00056960
• Code UNSPSC : 41106305
• ID de substance PubChem : 24891180
• Nomenclature NACRES : NA.51

Propriétés

• Source biologique: synthetic (organic)
• Niveau de qualité: 200
• Essai: ≥93%
• Forme: powder
• Solubilité: 0.2 M HCl: 50 mg/mL, clear, colorless to faintly yellow
• Température de stockage: −20°C
• Chaîne SMILES: Nc1ncnc2n(cnc12)C(OC(CO)C=O)C=O
• InChI: 1S/C10H11N5O4/c11-9-8-10(13-4-12-9)15(5-14-8)7(3-18)19-6(1-16)2-17/h1,3-7,17H,2H2,(H2,11,12,13)
• Clé InChI: ILMNSCQOSGKTNZ-UHFFFAOYSA-N

Description

Application

Adenosine, periodate oxidized has been used:

• as a methylarginine transferase inhibitor in the human embryonic kidney (HEK)-293 T cells
• as a methylase inhibitor in H4 neuroglioma
• as a broad inhibitor of S-adenosylmethionine (AdoMet)-dependent methyltransferases in mouse embryo fibroblast NIH3T3 cells

Actions biochimiques/physiologiques

Adenosine, periodate oxidized (Adox) is a protein arginine methyltransferases (PRMTs) inhibitor. It also inhibits the enzyme S-adenosylhomocysteine hydrolase and induces apoptosis. Its inhibitory effect on histone methyltransferases prevents histone methylation. Adox also elicits intrinsic cytotoxic properties.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Faceshields, Gloves, type N95 (US)