A7470

Anticorps anti-c-Myc

affinity isolated antibody

• Synonyme(s) : Anti-c-Myc
• Code UNSPSC : 12352203
• Nomenclature NACRES : NA.56

Propriétés

• Source biologique: rabbit
• Niveau de qualité: 200
• Conjugué: agarose conjugate
• Forme d'anticorps: affinity isolated antibody
• Type de produit anticorps: primary antibodies
• Clone: polyclonal
• Espèces réactives: human
• Classe(s) chimique(s) de l'analyte: proteins (c-Myc)
• Technique(s): affinity chromatography: suitable; immunoprecipitation (IP): suitable
• Capacité: ≥10 nmol/mL binding capacity (c-Myc tagged fusion protein); ≥7 nmol/mL elution capacity (c-Myc tagged fusion protein)
• Numéro d'accès UniProt: P01106
• Température de stockage: 2-8°C
• Informations sur le gène: human ... MYC(4609)

Description

Description générale

The human c-Myc proto-oncogene belongs to MYC oncogene family and is the human cellular homolog of the avian v-Myc gene found in several leukemogenic retroviruses. c-Myc gene is localized on human chromosome 8q24.21. The two major domains of include the N-terminal box regions and the C-terminal basic-region with helix-loop-helix/leucine-zipper motif.

Spécificité

Anti-c-Myc recognizes an epitope located on c-Myc tagged fusion proteins.

Immunogène

peptide synthétique de la protéine p62^c-Myc humaine.

Application

Anti-c-Myc Agarose Affinity Gel antibody produced in rabbit has been used in:

• chromatin immunoprecipitation (ChIP)
• co-immunoprecipitation
• western blotting
• immunofluorescence
• immunoprecipitation

Actions biochimiques/physiologiques

c-Myc proto-oncogene increased expression is observed in a variety of human tumors. Amplification of Myc gene locus is observed in angiosarcomas and translocation is implicated in Burkitt′s lymphoma. c-Myc is a master regulator and targets a wide variety of metabolic events. An epitope located within amino acid residues 410-419 (EQKLISEEDL) of human c-Myc has been widely used as a tag in many expression vectors, enabling the expression of proteins as c-Myc tagged fusion proteins. Anti-c-Myc agarose is useful in the purification of expressed c-Myc tagged fusion proteins in bacterial lysates or transfected cells.

Forme physique

Suspension of beaded agarose (1:1 v/v) in 0.01 M phosphate buffered saline containing 15 mM sodium azide.

Stockage et stabilité

For continuous use and extended storage, store at 2 °C to 8 °C. Do not freeze.

Autres remarques

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Clause de non-responsabilité

Unless otherwise stated in our catalog, our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable