A8861

Aceclofenac

≥98% (HPLC)

• Synonyme(s) : 2-[(2,6-Dichlorophenyl)amino]benzeneacetic acid carboxymethyl ester;
• Formule empirique (notation de Hill) : C₁₆H₁₃Cl₂NO₄
• CAS Number: 89796-99-6
• Poids moléculaire : 354.18
• Numéro MDL: MFCD00864296
• Code UNSPSC : 12352200
• ID de substance PubChem : 329771021
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: powder
• Couleur: off-white to light tan
• Solubilité: DMSO: ≥20 mg/mL
• Température de stockage: room temp
• Chaîne SMILES: OC(=O)COC(=O)Cc1ccccc1Nc2c(Cl)cccc2Cl
• InChI: 1S/C16H13Cl2NO4/c17-11-5-3-6-12(18)16(11)19-13-7-2-1-4-10(13)8-15(22)23-9-14(20)21/h1-7,19H,8-9H2,(H,20,21)
• Clé InChI: MNIPYSSQXLZQLJ-UHFFFAOYSA-N
• Informations sur le gène: human ... PTGS2(5743)

Description

Application

Aceclofenac (ACE) has been used as an internal standard in the in vivo blood-brain barrier assay. It has also been used to study the interaction of ACE with bovine serum albumin (BSA) by using spectroscopic techniques in combination with computational methods.

Actions biochimiques/physiologiques

Aceclofenac is a phenyl acetic acid derivative used for treating symptoms like swelling, tenderness, and stiffness due to muscle-skeletal and bone-related diseases (rheumatoid arthritis, juvenile arthritis, osteoarthritis, and acute gouty arthritis). This compound shows analgesic and antipyretic properties. Aceclofenac suppresses prostaglandin biosynthesis.

Non-steroidal, anti-inflammatory drug (NSAID), with selectivity for COX-2 over COX-1.

Informations sur la sécurité

• Pictogrammes: GHS06,GHS09
• Mention d'avertissement: Danger
• Mentions de danger: H301,H319,H410
• Conseils de prudence: P264 - P273 - P280 - P301 + P310 - P305 + P351 + P338 - P337 + P313
• Classification des risques: Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2
• Code de la classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable