A9789

Anisomycin

from Streptomyces griseolus, ≥98% (HPLC), solid, protein synthesis inhibitor

• Synonyme(s) : (2R,3S,4S)-2-(4-Methoxybenzyl)-3,4-pyrrolidinediol-3-acetate, 2-[(4-Methoxyphenyl)methyl]-3,4-pyrrolidinediol 3-acetate, Flagecidin
• Formule empirique (notation de Hill) : C₁₄H₁₉NO₄
• CAS Number: 22862-76-6
• Poids moléculaire : 265.30
• Beilstein: 20705
• Numéro CE : 245-269-7
• Numéro MDL: MFCD00077650
• Code UNSPSC : 12352200
• ID de substance PubChem : 24891496
• Nomenclature NACRES : NA.77

Propriétés

• Product Name: Anisomycin from Streptomyces griseolus, ≥98% (HPLC), solid
• Niveau de qualité: 300
• Essai: ≥98% (HPLC)
• Forme: solid
• Couleur: white to faint yellow
• Solubilité: H₂O: 2 mg/mL (Aqueous solutions are stable over a wide range of pH at room temperature.); DMSO: 20 mg/mL; methanol: 20 mg/mL
• Spectre d'activité de l'antibiotique: neoplastics
• Mode d’action: protein synthesis | interferes
• Température de stockage: 2-8°C
• Chaîne SMILES: COc1ccc(C[C@H]2NC[C@H](O)[C@H]2OC(C)=O)cc1
• InChI: 1S/C14H19NO4/c1-9(16)19-14-12(15-8-13(14)17)7-10-3-5-11(18-2)6-4-10/h3-6,12-15,17H,7-8H2,1-2H3/t12-,13+,14+/m1/s1
• Clé InChI: YKJYKKNCCRKFSL-RDBSUJKOSA-N

Description

Actions biochimiques/physiologiques

Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.

Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. Reported to induce apoptosis in a variety of cells including promyelocytic leukemia cells, Jurkat cells, ventricular myocytes, and colon adenocarcinoma cells. Initiates intracellular signals and immediate early gene induction. Selective signaling agonist. Potent Jun-NH₂ terminal kinase (JNK) agonist. Activates mitogen-activated protein (MAP) kinases (JNK/SAPK and p38/RK). Antiprotozoal agent.

Attention

Hygroscopic

Informations sur la sécurité

• Pictogrammes: GHS06
• Mention d'avertissement: Danger
• Mentions de danger: H301
• Conseils de prudence: P264 - P270 - P301 + P310 - P405 - P501
• Classification des risques: Acute Tox. 3 Oral
• Code de la classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges