B1401

Bradykinin Fragment 1-5

≥97% (HPLC)

• Formule empirique (notation de Hill) : C₂₇H₄₀N₈O₆
• CAS Number: 23815-89-6
• Poids moléculaire : 572.66
• Numéro MDL: MFCD00076260
• Code UNSPSC : 12352200
• ID de substance PubChem : 24891591
• Nomenclature NACRES : NA.32

Propriétés

• Niveau de qualité: 200
• Essai: ≥97% (HPLC)
• Forme: powder
• Numéro d'accès UniProt: P01042
• Température de stockage: −20°C
• Chaîne SMILES: NC(CCCNC(N)=N)C(=O)N1CCCC1C(=O)N2CCCC2C(=O)NCC(=O)NC(Cc3ccccc3)C(O)=O
• InChI: 1S/C27H40N8O6/c28-18(9-4-12-31-27(29)30)24(38)35-14-6-11-21(35)25(39)34-13-5-10-20(34)23(37)32-16-22(36)33-19(26(40)41)15-17-7-2-1-3-8-17/h1-3,7-8,18-21H,4-6,9-16,28H2,(H,32,37)(H,33,36)(H,40,41)(H4,29,30,31)
• Clé InChI: USSUMSBPLJWFSZ-UHFFFAOYSA-N
• Informations sur le gène: human ... KNG1 (includes EG:3827)

Description

Amino Acid Sequence

Arg-Pro-Pro-Gly-Phe

Actions biochimiques/physiologiques

The bradykinin (BK) fragment (1-5) (RPPGF) is among the most stable of naturally occurring metabolites. It may be used as a marker for BK production in vivo. It is known that an intact Arg residue in the C-terminus is required for biological activities. BK 1-5 is the minimal peptide that inhibited α-thrombin-induced platelet aggregation and secretion and calcium mobilization. It also prevented α-thrombin from cleaving the thrombin receptor peptide, NATLDPRSFLLR, between arginine and serine. Such antithrombin activities of BK 1-5 may contribute to the cardioprotective nature of kinins.

Conditionnement

Bottomless glass bottle. Contents are inside inserted fused cone.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)