B1760

Benzo[a]pyrène

≥96% (HPLC)

• Synonyme(s) : 3,4-benzpyrène, Benzo[def]chrysène
• Formule empirique (notation de Hill) : C₂₀H₁₂
• CAS Number: 50-32-8
• Poids moléculaire : 252.31
• Beilstein: 1911333
• Numéro CE : 200-028-5
• Numéro MDL: MFCD00003602
• Code UNSPSC : 12352005
• ID de substance PubChem : 24891610
• Nomenclature NACRES : NA.25

Propriétés

• Niveau de qualité: 200
• Essai: ≥96% (HPLC)
• Forme: solid
• pb: 495 °C (lit.)
• Pf: 177-180 °C (lit.)
• Chaîne SMILES: c1ccc2c(c1)cc3ccc4cccc5ccc2c3c45
• InChI: 1S/C20H12/c1-2-7-17-15(4-1)12-16-9-8-13-5-3-6-14-10-11-18(17)20(16)19(13)14/h1-12H
• Clé InChI: FMMWHPNWAFZXNH-UHFFFAOYSA-N

Description

Application

Benzo[a]pyrene (PAH), a polycyclic aromatic hydrocarbon pollutant, is used as a chemical carcinogen in experimental models of cancer. Carcinogenesis depends on it′s oxidation by CYP1A1 to benzo[a]pyrenediolepoxide, that forms depurinating adducts with DNA that dissociate to form abasic lesions. Benzo[a]pyrene is a ligand for the arylhydrocarbon receptor (AhR), and some of its biological effects, including the induction of CYP1A1, appear to be mediated via activation of the AhR.

Informations sur la sécurité

• Pictogrammes: GHS08,GHS07,GHS09
• Mention d'avertissement: Danger
• Mentions de danger: H317,H340,H350,H360FD,H410
• Conseils de prudence: P202 - P261 - P273 - P280 - P302 + P352 - P308 + P313
• Classification des risques: Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1B - Muta. 1B - Repr. 1B - Skin Sens. 1
• Code de la classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable