B5399

(±)-Baclofen

≥98% (HPLC), solid

• Synonyme(s) : (±)-β-(Aminomethyl)-4-chlorobenzenepropanoic acid, Lioresal
• Formule empirique (notation de Hill) : C₁₀H₁₂ClNO₂
• CAS Number: 1134-47-0
• Poids moléculaire : 213.66
• Numéro CE : 214-486-9
• Numéro MDL: MFCD00055143
• Code UNSPSC : 12352200
• ID de substance PubChem : 24278146
• Nomenclature NACRES : NA.32

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: solid
• Couleur: white to very faintly yellow
• Solubilité: 1 M HCl: 50 mg/mL
• Température de stockage: 2-8°C
• Chaîne SMILES: ClC1=CC=C(C(CN)CC(O)=O)C=C1
• InChI: 1S/C10H12ClNO2/c11-9-3-1-7(2-4-9)8(6-12)5-10(13)14/h1-4,8H,5-6,12H2,(H,13,14)
• Clé InChI: KPYSYYIEGFHWSV-UHFFFAOYSA-N
• Informations sur le gène: human ... GABBR1(2550), GABBR2(9568) ; rat ... Gabbr1(81657), Gabra2(29706)

Description

Application

(±)-Baclofen has been used as γ-aminobutyric acid receptor B GABA_B receptor agonist:

• as well as control GABAergic drug to test its protective effects on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic toxicity
• to test its effects on in vivo motor function tests and performance of mutant mice
• to test its excitability effect on dopaminergic (DA) neurons of the ventral tegmental area (VTA)
• to test its effect in reducing dendritic excitability in Purkinje neurons

Actions biochimiques/physiologiques

Baclofen, a γ-aminobutyric acid (GABA) analog, possesses myorelaxant properties Being a γ-aminobutyric acid receptor B (GABA_B) agonist, baclofen may be involved in the potentiation of dendritic potassium K⁺ channels. It may be useful in blocking transient lower esophageal sphincter relaxation (TLESR) in gastroesophageal reflux disease (GERD). Baclofen may also have scope for treating addictive especially, in alcohol use disorder (AUD).

GABA_B receptor agonist; skeletal muscle relaxant; antispastic agent.

Informations sur la sécurité

• Pictogrammes: GHS06
• Mention d'avertissement: Danger
• Mentions de danger: H301
• Conseils de prudence: P264 - P270 - P301 + P310 - P405 - P501
• Classification des risques: Acute Tox. 3 Oral
• Code de la classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges