B8385

Bestatin hydrochloride

powder, ≥98% (HPLC)

• Synonyme(s) : N-[(2S,3R)-3-Amino-2-hydroxy-4-phenylbutyryl]-L-leucine hydrochloride
• Formule empirique (notation de Hill) : C₁₆H₂₄N₂O₄ · HCl
• CAS Number: 65391-42-6
• Poids moléculaire : 344.83
• Beilstein: 4628066
• Numéro MDL: MFCD00058004
• Code UNSPSC : 12352202
• ID de substance PubChem : 24278278
• Nomenclature NACRES : NA.77

Propriétés

• Product Name: Bestatin hydrochloride, ≥98% (HPLC)
• Source biologique: synthetic (organic)
• Niveau de qualité: 300
• Essai: ≥98% (HPLC)
• Forme: powder
• Pf: 216 °C
• Solubilité: water: 25 mg/mL, clear to very slightly hazy, colorless
• Spectre d'activité de l'antibiotique: neoplastics
• Mode d’action: enzyme | inhibits
• Température de stockage: −20°C
• Chaîne SMILES: O=C(N[C@@H](CC(C)C)C(O)=O)[C@@H](O)[C@H](N)CC1=CC=CC=C1.Cl[H]
• InChI: 1S/C16H24N2O4.ClH/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11;/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22);1H/t12-,13+,14+;/m1./s1
• Clé InChI: XGDFITZJGKUSDK-UDYGKFQRSA-N

Description

Description générale

Chemical structure: amino acid derivatives

Actions biochimiques/physiologiques

A metalloprotease inhibitor selective for aminopeptidase. Bestatin is a competitive and specific inhibitor of leucine aminopeptidase, aminopeptidase B, and triamino peptidase. It inhibits aminopeptidase B at 60 nM (using arginine-β-naphthylamide as substrate) and leucine aminopeptidase at 20 nM (leucine-β-naphthylamide as substrate). It showed no inhibition of aminopeptidase A, trypsin, chymotrypsin, elastase, papain, pepsin, or themolysin. It offers promise as a novel analgesic because it protects endogenous opioid peptides against degradation.

Notes préparatoires

Solubility testing in water at 25 mg/ml yields a clear solution. Stock solutions at 1 mM are expected to be stable at least one month stored at -20 °C.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)