B8562

BD 1047 dihydrobromide

≥95% (HPLC)

• Synonyme(s) : BD 1047 dihydrobromide
• Formule empirique (notation de Hill) : C₁₃H₂₀Cl₂N₂ · 2 HBr
• CAS Number: 138356-21-5
• Poids moléculaire : 437.04
• Numéro MDL: MFCD00792739
• Code UNSPSC : 12352200
• ID de substance PubChem : 329773309
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥95% (HPLC)
• Forme: powder
• Conditions de stockage: desiccated
• Couleur: white
• Solubilité: H₂O: >5 mg/mL
• Température de stockage: 2-8°C
• Chaîne SMILES: Br.Br.CN(C)CCN(C)CCc1ccc(Cl)c(Cl)c1
• InChI: 1S/C13H20Cl2N2.2BrH/c1-16(2)8-9-17(3)7-6-11-4-5-12(14)13(15)10-11;;/h4-5,10H,6-9H2,1-3H3;2*1H
• Clé InChI: WOALTFHGLDVJHK-UHFFFAOYSA-N

Description

Application

BD 1047 dihydrobromide has been used as an antagonist of sigma-1 receptor in hepatocellular carcinoma cells.

BD 1047, a selective, putative σ1 receptor antagonist, is used in sigma receptor research to help differentiate and characterized the function and role of the sigma1 receptor versus other sigma receptor subtypes. BD 1047 is used to help define the role of σ1 receptors in neurological processes.

Actions biochimiques/physiologiques

BD-1047 is a selective, putative σ receptor antagonist with antidystonic activity.

BD-1047 is a selective, putative σ receptor antagonist with antidystonic activity. BD-1047 has >50-fold selectivity at σ1 over σ2 and also >100-fold selectivity over opiate, phencyclidine, muscarinic, dopamine, α1- & α2-adrenoceptor, 5-HT1, and 5-HT2. Though s receptor antagonism is consistent with antipsychotic, especially anti-schizophrenic, activity, BD-1047 shows only modest activity in animal screens for antipsychotics.

In human immunodeficiency (HIV)-1 seropositive patients, BD 1047 along with other antioxidants may aid in reduction of cathepsin B- based neuropathology.

Informations sur la sécurité

• Pictogrammes: GHS05,GHS07
• Mention d'avertissement: Danger
• Mentions de danger: H315,H318,H335
• Conseils de prudence: P280 - P302 + P352 - P305 + P351 + P338 + P310
• Classification des risques: Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
• Organes cibles: Respiratory system
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable